The renin-angiotensin system is powerful regulator of blood pressure homeostasis. An article published in the March 24 issue of JASN highlights an emerging area of research into the modulation of AT1 receptors on different tissues.
The majority of well-known angiotensin II actions are mediated via AT1 receptor stimulation, and angiotensin converting enzyme inhibitors (ACEi) and AT1 receptor blockers (ARBs) have been widely used as antihypertensive agents with cardiovascular protective effects. Elucidating factors that regulate AT1 receptor expression levels in different tissue compartments will hopefully lead to novel agents to treat hypertension and its associated end-organ damage (ESRD, CHF and Stroke). Recent studies have demonstrated the existence of several proteins interacting with AT1 receptors that may modulate AT1 receptor expression level, sensitivity and internalization. A recent review article highlights this emerging field. Atrap (AT1 receptor-associated pin vivo