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HIV Breakthrough at Houston Med School

Posted Feb 19 2009 8:33am

There is real hope that what’s happening in a Houston lab might lead to a cure for HIV. HIV AIDS Research story and video

Researcher holds test tubes with separated HIV infected blood.  “We have found an innovative way to kill the virus by finding this small region of HIV that is unchangeable,” Dr. Sudhir Paul of the University of Texas Medical School at Houston said.

Dr. Paul and Dr. Miguel Escobar aren’t talking about just suppressing HIV – they’re talking about destroying it permanently by arming the immune system with a new weapon lab tests have shown to be effective.

Ford Stuart has been HIV positive for 15 years. He’s on a powerful drug cocktail that keeps the disease in check.

Dr. Paul thinks he’s cracked a code.

“We’ve discovered the weak spot of HIV,” he said. Paul and his team have zeroed in on a section of a key protein in HIV’s structure that does not mutate.  “The virus needs at least one constant region, and by taking advantage of something called an abzyme. It’s naturally produced by people, like lupus patients. When they applied that abzyme to the HIV virus, it permanently disarmed it.

“What we already have in our hand are the abzymes that we could be infusing into the human subjects with HIV infection, essentially to move the virus,” Paul said.

Basically, their idea could be used to control the disease for people who already have it and prevent infection for those at risk.

The theory has held up in lab and animal testing. The next step is human trials.  “If we can get the viral loads down to a manageable level, that will preclude the need for these conventional drugs,” Escobar said.

Still, even if everything goes well, it’s at least five years before the research could help people with HIV.

The doctors know there are millions of people waiting.

“There are so many people struggling with the disease because it affects not only your body, but also your psyche, how you perceive yourself,” he said.

If nothing else, the research is promising for the tens of millions waiting for a cure.

 

XLPharmacy side note: 

 

Today we at XLPharmacy beseech anyone who is able to consider a contribution to this research.  Research is very expensive and there are millions waiting.  When HIV and AIDS was first diagnosed HIV patients would live between a few months to a few years after diagnosis.

 

With modern day therapy, that maintains a safe level of the HIV viral load, an HIV infected individual can live a normal adult lifespan but will have to take antiretroviral drugs every day of their lives. If this breakthrough that Houston has found can find the enormous amount of funding it is going to need, we are certain that the future of millions will be so much brighter. - XLPharmacy

 

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