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What are the differential diagnosis for intraluminal filling defect in coronary angiogram ?

Posted Mar 07 2009 2:57pm

Intraluminal filling defect is often  observed during coronary angiogram .Thrombosis  has become the default diagnosis in most situations.This has resulted in over diagnosis of thrombosis .In fact a strategically located plaque stained by the dye is an equally common cause for intraluminal filling defect.

In fact there are many recognised caused of filling defect

  1. Thrombus
  2. Dissection
  3. An eccentric plaque
  4. Dye trapped within  plaque fissures
  5. Calcification projecting into lumen
  6. Plaque prolapse from stent struts
  7. Artifacts-End on view of  side branches
  8. Static myocardial bridges
  9. Trapped air bubble(Transient filling defect)
  10. Streaming  effect  dye may mimic a filling defect


It is  no t advicable  to make a  default dignosis of coronary thrombosis in all cases of intraluminal filling defects

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