A. Tracleer (bosentan) is the first oral medication in the treatment of PH. Tracleer was FDA-approved in 2001. Tracleer works to block the effects of endothelin, a substance found in excess in a PH patient. Endothelin causes the blood vessels to constrict. Using Tracleer helps to relax the blood vessels, reducing blood pressure in the lungs, and increasing functionality in the PH patient. Tracleer is taken twice daily, and monthly bloodwork must be done in order to make sure liver function is not being affected.
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