Researchers from University of Hawaii at Manoa and University of Hawaii discovered a molecular pathway that might help reduce the damaging effects of cardiac hypertrophy. They have found that stretch of adult cardiac cells promotes release of VEGF through activation of the NFkB signaling pathway. The pathological effects of hypertrophy might be alleviated and the survival chances could be increased for patients who have had a heart attack or suffer hypertension if doctors could target at this molecular pathway.
Funded by the National Center for Research Resources (part of the National Institutes of Health), the study was published on December 13, 2011 in medical journal ‘PLoS ONE’.
As reported by The Burden of Heart Disease in Hawaii, more than 3,100 people in Hawaii die of cardiovascular disease every year, and as many as 70 percent of the adults in Hawaii have at least one risk factor for cardiovascular disease, including diabetes, hypertension and obesity. According to Hawai'i State Department of Health, residents of Hawaii Island, Native Hawaiians, Filipinos, and the poor have higher risks for cardiovascular disease.
Of course, there are many ways that people could lower their risk for heart disease. These include lowering high blood pressure, reducing high bad cholesterol (LDL), staying away from cigarette smoking, engaging in adequate physical activity, managing diabetes, eating healthy diets and maintaining healthy weight.