Hashimoto's Hypothyroidism and Oprah Winfrey
I love Oprah. My sister 'M' loves Oprah. It would be a gigantic understatement to say that all my girlfriends and co-workers love Oprah.
Now, with that said, I feel extremely, deeply saddened when I see the most well connected woman and influential/popular educator sooooo disconnected with her health and hormones. Have you been there? Unable to control your body or weight? Like a typical Oprah nut, I spent a few nights madly emailing her about year ago in Jan 2008 about vitamin D and weight loss and optimal health (and my 50# weight loss story ). Where did it go? Filed in the big phat Oprah-empire round file??
Who has not been in her precise shoes?
Read about Oprah's Thyroid Club HERE (NY Times).
Hashimoto's hypothyroidism is one of the most common female (and male) afflictions of the late 20th and 21st centuries. Nearly every one of my diabetes patients has Hashimoto's.
Why are 45+ million Americans burning their Thyroid to a toast, like Oprah?
In my 20's -- stressed, eating dorm food, trying do everything 'right', instead of gaining the freshman 'fifteen', I gained F-O-R-T-Y lbs (because... hey... I'm an overachiever).
[Another college curiosity was observing how my hormones/ cycles/ periods became imperceptibly and immutably N*SYNC with my female dorm-mates. Mense shifts are apparently secondary topineal glandandpheromones(link and other refs from an astute friend, thanxxx dude). Recall, pheromones are picked up by the nose-vomeronasal systemand subsequenthypothalamus/limbic brain(paleopallium).]
What was going on with that college weight gain, mood fluctuations, difficult concentrating, fatigue, coarse hair/skin, skin tag growth/insulin resistance, cold intolerance, resistance to weight loss/exercise, high cholesterol, and general feeling of clinical cr*ppiness??
!!I wish I knew back then...!!
Oprah... let's try to clue you in, my honeybun... from my own lessons.
For me, in hindsight, there were a few situations that may parallel Oprah's, that are backed up by the medical literature that cause thyroid dysfunction: --lack of sunlight/vitamin D/indoor habitation
--sleep deprivation... (excessive mochas/lattes at Berkeley cafes)
--excessive 'social' calendar
--inherent family history of autoimmune disorders (who doesn't??)
--wheat, wheat, and more wheat ingestion ('comfort foods' craved in times of high cortisol/stress, right?)
--lack of nutritious food containing EPA DHA, vitamin A, sat fats, minerals, iodine, etc
--lack of play, exercise, movement (or ?overtraining perhaps for Oprah's case)
--weight gain -- which begins an endless self-perpetuating vicous cycle of all the above (Is it stressful to balloon out for no apparent reason? YES)
Of course, it turns out there is a hheeeyyuuggee link between sunlight/vit D/melatonin and the neuroendocrine system.
Our dear Dr.Davis has spent a great deal of time discussing both integral hormones which regulate our neuroendocrine system:
(1) Hormone of Light - Vitamin D
(2) Hormone of Darkness - Melatonin
These four research groups below discuss how our Hypothalamus-Pituitary-Thyroid-Gonad Axis is tightly affected by melatonin, Thyroid Hormones, neuropeptides like brain tachykinins, and our reproductive sex steroids (Estrogen and Testosterone).
Melatonin influences on the neuroendocrine-reproductive axis.
Oprah Needs Vitamin D
Vitamin D ties everything together. The above two pictures come from the below research article ( Sunlight--can it prevent as well as cause cancer? ). The authors review: "The active form, 1.25D,, is a full member of the endocrine system, and as such interacts with virtually every organ in the body (31, 32). Especially noteworthy is its interaction with the sex and pituitary hormones (32-34), e.g.,the promotion of l-a-hydroxylation of 25D, by prolactin (34), since some of these interactions provide a mechanism for participation of 1.25D, in the control of cell growth in the reproductive organs . . . The Darwinian view of evolution suggests that loss of body hair in Homo sapiens should have some survival advantage, and it is difficult to think of reasons other than that this provides ready access of sunlight to the skin . . . lack of sufficient sunlight contributes to the known high incidence of carcinoma of the prostate in black American men and to the more aggressive progression of carcinoma of the breast in black women."
Vitamin D interacts with all the steroid nuclear receptors especially Thyroid Receptors and Vitamin A/Carotenoid Receptors ( The concept of multiple vitamin D signaling pathways. Carlberg C. J Investig Dermatol Symp Proc. 1996 Apr;1(1):10-4.)
Oprah has a few risk factors for low blood vitamin D:
--stress -- our body burns up Vitamin D to maintain cellular processes under stress and infections
--wheat consumption (Stephan discusses this very well: Vitamin D and Celiac/Gluten Sensitivity )
--living north of the 37th latitude where UVB solar radiation is scarce for 50% of the calendar year
Unless Oprah is receiving bio-identical hormone replacement, then her natural steroid sex hormones are likely to be 'off' and this would affect her Thyroid as well. Women from age 35 yo and up start experiencing declines in sex hormone due to the atresia (dissolving) of the eggs in the ovaries, one of the main sources of Estrogen and Testosterone. After Menopause (average age: 51 yo), nearly all eggs are gone. Again, as the above emphasizes, the lack of significant sex hormones will profoundly affect the Hypothalamus-Pituitary-Thyroid glands.
What can help Oprah's Thyroid and take her to optimal health?
--Richard at Free the Animal started this conversation and many of his fans chimed in. Scott Miller writes:
"Here are ten quick mistakes I see her making that will sabatoge her efforts:
Besides the paleolithic lifestyle, Oprah could use some natural neolithic bio-identical hormone replacement, starting with the big 'D':
--Vitamin D to blood [25(OH)D = 70 ng/ml] which will probably require about 8000 IU daily in the morning (Cannell doses 1000 IU per 25 lbs -- Oprah reports weight is ~200 lbs)
--Cortisol Reduction -- rest, relaxation, meditation, turn off the Crackberry
--Correct hGH Deficiency-- eat more fat/protein, carb restrict, sleep well and enough
--THYROID Replacement-- correct gradually to tolerance and mood, energy, vitality and cognition
--Estrogen (estriol E3 primarily) -- correct perimenopausal changes
--Natural Progesterone -- calms and restores all the other cycles (avoid Provera, Levonorgestrol -- synthetic progestins are associated with cancer and lower HDL 20-30%)
--Testosterone -- replace for mood, affiliation and libido
How to Stop the Autoimmune Process of Hashimoto's
When one of our organs is jacked how do we recover it? Can we induce our immune system to heal and restore function? Certainly! With time, appropriate nutrients and stimulus, I believe depending on the extent of the incurred damage, our bodies have the capacity to regenerate itself. With Vitamin D repletion and Wheat-Cessation, I have observed a trend of improved TSH (including my own from 1.3-1.9 to 1.0 when my 25(OH)D stays above 60 ng/ml). Why? Vitamin D interacts intimately with thyroid, vitamin A/carenoid and other steroid hormone controls, including the sex hormones.
These below nutrients and lifestyle changes have been shown to aid the Thyroid to heal and restore functionality:
-stopping beans, peanuts, legumes (lectins)
-stopping dairy (which contain opioid-like proteins like wheat)
-stopping grains ( rice, corn, etc) -- which are grass-derived (*ha * I didn't say WEED )
-proper nutrients which are the build-blocks of the Thyroid Gland and Thyroid Enzymes: proteins (taurine, leucine, etc), minerals (IODINE, Mg, Zn, Se, etc)
-Carotenoids (grassfed meat, wild seafood, Krill oil/Astaxanthin)
- EPA + DHA (ditto) -- high dose if extreme inflammation is present
- Antioxidants (Pycnogenol, Quercetin, CoQ10, ALCAR/a-LA, etc)
-Avoid dietary and environmental toxins (nitrite preservatives, plastic, petroleum, bisphenol, Lead, Mercury, endocrine disrupters, pesticides, etc)
Hashimoto's Thyroiditis Related to Autoimmune Genes
All autoimmune conditions are related to differences in our immune system. Even Migraines are associated with a certain type of immunity variation (Prevalence of HLA DQB1*0602 allele in patients with migraine). Hashimoto's is strongly tied to HLA DR5 types, vitamin D receptor anomalies, and CYP1 alpha hydroxylase (vitamin D activation enzyme) variations. It turns out also that Addison's Disease is tied to the same Cyp enzyme variant or what is known as a polymorphism.
A promoter polymorphism of the CYP27B1 gene is associated with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans.
Association of vitamin D receptor gene 3'-variants with Hashimoto's thyroiditis in the Croatian population.
Vitamin D receptor gene polymorphisms are associated with risk of Hashimoto's thyroiditis in Chinese patients in Taiwan.
Vitamin D receptor genotype is associated with Addison's disease.
Vitamin D 1alpha-hydroxylase (CYP1alpha) polymorphism in Graves' disease, Hashimoto's thyroiditis and type 1 diabetes mellitus.
Vitamin D receptor gene polymorphisms in Hashimoto's thyroiditis.
[Genetic markers in thyroid autoimmune diseases]
Steve Jobs: Addison's Disease?
Via Apple headquarters, Mr. Jobs issued a statement reporting that he was receiving treatment for 'protein wasting' for what doctors believed was caused by a 'hormonal imbalance.' He states he does not have cancer. Could Mr. Jobs be suffering from the same ailment as our late great president John F Kennedy? Mr. Jobs was reported to consume a vegetarian diet which are often devoid of EPA and DHA -- protectors against autoimmune disease as well as pancreatic cancer (see below). EPA and DHA are long chain omega-3 polyunsaturated fatty acids (PUFA) which ONLY come from animal sources. EPA and DHA are like Comcast and DSL -- they provide the reliable high-spped connections for electronic conductions in our nervous systems (compare v. lame lowtech modem/omega-6). Our brain is comprised of inordinate amounts of DHA and EPA. Every cell membrane. Unfortunately humans do not induce enough of the enyzmes to convert vegetarian omega-3 ALA to EPA + DHA in our bodies. If you are not stressed, then it is unlikely to matter. ALA from vegetarian sources would sufficiently maintain health. Most people however undergo some degree of stress or oxidative damage from daily living (like...umm...breathing or... doing Crossfit or HIIT). Although Mr. Jobs apparently did not have the most aggressive form of pancreatic cancer, he had surgery a few years ago for a neuroendocrine tumor in the pancreas. Addison's may also originate from metastatic tumors to the adrenal glands.
Has Mr. Jobs been under stress? Maybe...
(1) Cancer survivor
(2) Rolled out the best neolithic tech advances: iPOD, iPHONE
(3) Apple innovator/revivor/evolver
Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells.
Omega-3 fatty acids improve liver and pancreas function in postoperative cancer patients.
Fish oil and treatment of cancer cachexia.
Do you want Pancreatic Cancer??
Consume a lotta Omega-6 refined veggie oils like Sunflower or Safflower oil
and/or develop Omega-3 Deficiency
and/or eat a lot of Fructose
and/or a USDA Whole Grain Diet:
Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth.
Effect of dietary omega-3 and omega-6 fatty acids on development of azaserine-induced preneoplastic lesions in rat pancreas.
Carcinogen-induced lesions in the rat pancreas: effects of varying levels of essential fatty acid.
Effect of dietary intake of fish oil and fish protein on the development of L-azaserine-induced preneoplastic lesions in the rat pancreas.
Dietary glycemic load, added sugars, and carbohydrates as risk factors for pancreatic cancer: the Multiethnic Cohort Study.
Dietary sugar, glycemic load, and pancreatic cancer risk in a prospective study.
Etiology of nonresponsive celiac disease: results of a systematic approach.
Aldolase C in neuroendocrine tumors: an immunohistochemical study.
Dietary fructose enhances the development of atypical acinar cell nodules in the pancreas of rats pretreated with N-nitrosomorpholine.
Hormone Imbalances and Organ Failure
Like Oprah, several hormonal imbalances can lead to organ failure due to an autoimmune process. In Addison's, the organ mainly affected is the adrenal glands which provide Cortisol and other cholesterol-derived hormones to the body. Without a minimal amount of Cortisol, we do not make muscles or store fat. Addison's leads to muscle wasting, weight loss, dizziness, and depression. Excessive Cortisol, on the other hand, causes a condition known as Cushing's where excessive abdominal weight gain, moon-face, thin-skin, muscle wasting, fatigue and insomnia occur.
Other Thyroid Sources:
Hormone Balancing Resources: