Weekly Health Update:
Hesperidin in Orange Juice Improves
Hypertension and Arterial Function
"A critical weekly review of important new research findings for health-conscious readers..."
The information in this column is intended for informational purposes only, and does not constitute medical advice or recommendations by the author. Please consult with your physician before making any lifestyle or medication changes, or if you have any other concerns regarding your health.
Welcome to Weekly Health Update
“A critical weekly review of important new research findings for health-conscious readers”
HESPERIDIN IN ORANGE JUICE IMPROVES
HYPERTENSION AND ARTERIAL FUNCTION
Polyphenols are chemical compounds that are found in most of the plant-based foods that we commonly eat. As I discuss in detail in my new book, A Cancer Prevention Guide for the Human Race, some polyphenolic compounds, such as green tea flavonoids, soy-based isoflavones, quercetin, curcumin, and resveratrol, among other polyphenols, may possess important cancer prevention properties. There is also abundant research data suggesting that diets rich in certain natural dietary polyphenols may be associated with a decreased risk of cardiovascular disease, as well.
Hesperidin, which is a flavonoid polyphenol, is found in a variety of plant-based foods, including oranges, orange juice, and other citrus fruits. A newly published prospective, randomized, blinded clinical research study, which appears in the current issue of the American Journal of Clinical Nutrition, offers intriguing evidence that hesperidin may actually decrease the risk of cardiovascular disease in high-risk patients.
In this pilot study, 24 overweight (but otherwise healthy) men, ages 50 to 65 years, were subjected to 4-week intervals in each of three experimental groups. The first group was assigned to drink 500 ml (17 ounces) of orange juice per day. The second experimental group drank a “control drink” that appeared similar to orange juice, but which did not contain any actual orange juice. However, this “sham orange juice” was fortified with hesperidin. The third group was also assigned to drink the fake orange juice, and to which was added a supplement portrayed (to the study volunteers, and to the research nurses who administered the beverages to these research volunteers) as hesperidin, but which, in fact, was an inert placebo that contained no hesperidin or other polyphenols.
Physical examinations and blood tests were performed before and after the men rotated through each of these three experimental groups.
The findings of this small but high quality clinical research study were quite interesting. When compared to the control group that consumed the fake orange juice and fake hesperidin supplement, the men in the other two experimental groups experienced a significant reduction in their blood pressure measurements. Specifically, the diastolic blood pressure was significantly reduced, which suggests that these men experienced an improvement in the elasticity, or compliance, of their arteries, as a direct result of the hesperidin contained in both orange juice and in the non-juice beverage supplemented with hesperidin. This observation was again confirmed through additional testing that revealed improved vascular compliance associated with hesperidin intake. Moreover, this significant improvement in arterial compliance was observed only after the ingestion of hesperidin, and disappeared when these same men were retested after undergoing an overnight fast. (Improved arterial compliance is associated with a reduced risk of cardiovascular disease, including high blood pressure, coronary artery disease, and stroke.)
To summarize the findings of this study, hesperidin, when taken in the form of either orange juice or as a supplement, appeared to significantly improve arterial elasticity, and lower diastolic blood pressure, in middle-aged overweight men. While this brief study cannot prove that these observed and transient improvements in arterial compliance subsequently reduced the incidence of cardiovascular disease in these high-risk men, there is abundant data from other research studies linking improved arterial compliance with a reduced incidence of cardiovascular disease. A much larger version of this small pilot study should now be repeated, and the volunteers in this larger study need to be followed for a much longer duration of time, before we can say, with certainty, that hesperidin significantly reduces the risk of cardiovascular disease. That being said, the findings of this small but well-conducted, and elegant, randomized, controlled, prospective clinical research study are still quite compelling.
For a complete discussion of the role of dietary flavonoids and polyphenols in cancer prevention, and other important evidence-based approaches to cancer prevention, order your copy of my new book,A Cancer Prevention Guide for the Human Race,now! For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!
GIVE THEGIFT OF HEALTH THIS HOLIDAY SEASON! For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book,“ A Cancer Prevention Guide for the Human Race,” from Amazon,Barnes & Noble, Books-A-Million, Vroman’s Bookstore, and other fine bookstores!
I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (As of 9/16/2010, more than 1,000,000 health-conscious people have logged onto Weekly Health Update so far this year!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.
Disclaimer: As always, my advice to readers is to seek the advice of your physicianbeforemaking any significant changes in medications, diet, or level of physical activity
Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author
For a different perspective on Dr. Wascher, please click on the following YouTube link:
Send your feedback to Dr. Wascher at:
Copyright 2007 - 2010
Robert A. Wascher, MD, FACS
All rights reserved
Dr. Wascher's Archives:
12-19-2010: Job and Workplace Stress
12-12-2010: Metformin, Diabetes and Death
12-5-2010: Vitamin D and Depression
11-14-2020: Low Dose Aspirin Reduces Colorectal Cancer Risk
11-7-2010: Coffee, Tea, Caffeine and Brain Cancer Risk
10-14-2010: Gum Disease (Gingivitis) and Breast Cancer Risk
10-3-2010: Mammograms Between 40 and 49 Years of Age
9-19-2010: Fruits and Vegetables Improve Memory
9-12-2010: Low-Carb Diet and Risk of Death
8-1-2010: Physician Error
7-25-2010: Obesity and Cancer Risk
6-27-2010: Soy, Curcumin & Prostate Cancer Risk
5-30-2010: Medical Research Studies & “Spin”
5-9-2010: Soy Foods & Stomach Cancer Risk
4-18-2010: Coffee Improves HDL Cholesterol Levels
3-28-2010: Aspirin & Breast Cancer Survival
3-21-2010: Obesity, Alcohol & Liver Disease
3-14-2010: Nuts, Diet & Obesity
2-28-2010: Soy Isoflavones & Recurrent Prostate Cancer
2-14-2010: Pancreatic Cancer Risk, Sodas & Juice
1-31-2010: Concord Grape Juice Improves Memory
1-24-2010: Mozart, Music, Babies & Health
1-17-2010: Breast Cancer, Physical Therapy & Lymphedema
1-3-2010: Ginkgo Biloba, Memory & Cognitive Health
12-20-2009: CT Scans & Cancer Risk
11-29-2009: Exercise & Prostate Cancer Risk
11-22-2009: Genistein (Soy Isoflavone) & Prostate Cancer
11-15-2009: Breast Cancer Treatment & Chronic Pain
1-8-2009: Vitamin D & Breast Cancer Risk
11-1-2009: Exercise & Prostate Cancer Risk
10-25-2009: HPV Virus & Risk of Breast Cancer
10-11-2009: Vitamin D & Falls in the Elderly
10-4-2009: Surgery, NSQIP, Complications & Death
9-27-2009 Stress, Heart Disease, Exercise & Death
9-20-2009: Vitamin D & Colorectal Cancer Survival
9-13-2009: H1N1 Swine Flu Update
9-7-2009: Green Tea, Aging & Lifespan
8-30-2009: Irritable Bowel Syndrome (IBS), Diet & Fiber
8-23-2009: Update on Prostate Cancer and Cryotherapy
8-2-2009: Honesty, Dishonesty & Brain Function
7-26-2009: Coronary Artery CT Scans & Cancer Risk
7-12-2009: Breast Cancer & Metformin (Glucophage)
7-5-2009: Prostate Cancer & Green Tea
6-21-2009: Red Yeast Rice, Statins & Cholesterol
6-7-2009: Diet, Soy & Breast Cancer Risk
5-31-2009: Diet and Prostate Cancer Risk
5-24-2009: Diabetes, Glucose Control & Death
5-10-2009: Hemorrhoids & Surgery
4-26-2009: Are We Really Losing the War on Cancer?
4-19-2009: Exercise in Middle Age & Risk of Death
4-12-2009: Can Chronic Stress Harm Your Heart?
3-15-2009: Depression, Stress, Anger & Heart Disease
10-26-2008: Smoking & Quality of Life
10-19-2008: Agent Orange & Prostate Cancer
10-12-2008: Pomegranate Juice & Prostate Cancer
9-21-2008: Does Tylenol® (Acetaminophen) Cause Asthma?
4-27-2008: Stents vs. Bypass Surgery for Coronary Artery Disease; The “DASH” Hypertension Diet & Cardiovascular Disease Prevention; Testosterone Therapy for Women with Decreased Sexual Desire & Function
4-13-2008: Breast Cancer Recurrence & Hormone Replacement Therapy (HRT); Carotid Artery Disease: Surgery vs. Stents?; Statin Drugs & Cancer Prevention
4-6-2008: Human Papilloma Virus (HPV), Pap Smear Results & Cervical Cancer; Human Papilloma Virus (HPV) Infection & Oral Cancer; Hormone Replacement Therapy (HRT) & the Risk of Gastroesophageal Reflux Disorder (GERD)
12-16-2007: Honey vs. Dextromethorphan vs. No Treatment for Kids with Night-Time Cough, Acupuncture & Hot Flashes in Women with Breast Cancer, Physical Activity & the Risk of Death, Mediterranean Diet & Mortality