I like Dr. Mao for his quickie Yahoo tidbits... His advice is great! And very aligned to TrackYourPlaque and longevity as well imho. Sometimes I wonder what's more important...our brain or our heart? Or the vasculature which is what we 'track' at TYP...? I'm grateful actually that ALL in fact improve exponentially with the same program.
How wonderful can life be?!? (G-radio: Mraz 'Wonderful Life' *wink*)
All the foods and nutrients listed below are inherent ingredients to heart reversal stories, "essential amino acids, omega oils, minerals and vitamins":
--Taurine from wild seafood and grassfed meat (not found in veggies)
--Other proteins: Leucine, BCAA, L-Carnitine, etc
--Omega-3 fatty acids: EPA DHA (grassfed meat, seafood); ALA (almonds)
--Omega-6 fatty acids: GLA (sesame oil, borage, primrose, hemp)
--Minerals: Magnesium, Iodine, Selenium, Zinc, Boron, Sulfur, etc
--Vitamins: Vitamin D (calcidiol), Vitamin A, Vitamin E (tocotrienols), Vitamin K1 K2 (esp MK7), methylated folic acid, B-vitamins, Niacin (B3), B6/B12/folic acid (homocysteine control), acetylated a-Lipoic Acid, etc
--Antioxidant Flavanoids: blueberries, green tea, pycnogenol, red wine, bilberry, et cetera
8 Foods to Keep Your Brain Young and Healthy
By Dr. Maoshing Ni - Posted on Mon, Aug 11, 2008, 1:42 pm PDT
Senility,Alzheimer's, and age-relatedmemory loss: these conditions of mental decline that come with aging can be delayed or even prevented. Besides engaging in daily activities that work out your brain, a regular and balanced diet rich with essential amino acids, omega oils, minerals and vitamins will ensure a vibrant and sharp memory. Eat these foods to give your brain the nutrition it needs.
Ketogenic Diet for Alzheimer's and other Neuro-degenerative/Vascular Diseases
Why is a ketogenic diet effective for neurodegenerative and vascular diseases (like CAD)? I've wondered this since Atkin's became so popular. I've also wondered why such extreme improvements are noticed short- and long-term with Niacin (Vitamin B3; we use either Slo-Niacin or Niaspan at TYP). This one incredible addition to any heart program evolves dramatic plaque remodelling, heart disease reversal, lipoprotein turn-arounds and large ranges of CAC score regressions. In the HATS trial in post-MI patients, Niacin + simvastatin 40mg/d brought about a 90% reduction in mortality and CAD events in ~3yrs compared with placebo. That is quite dramatic. The results are unheard of for conventional, pharmaceutical-derived therapies. Statin-monotherapy brings about only 20-30% depending on the study...which again as the latest WSJ article summarized...so what? These days when individuals carry belly fat and have elevated insulin, heart attacks and coronary surgical interventions are more de rigueur than NAUGHT... despite statins being placed in the water by health care insurances and people's demands.
What is niacin? Niacin mimics 2 things: starvation (living off your body fat/rearend) and ketosis. Niacin binds the ketone body receptor known as PUMA-G. Ketones are generated under many circumstances for instance:
--first 2 weeks of an infant's life -- baby is living on 60-80% brown fat b/c momma has produced enough milk yet (as the nipples get calloused up -- yeah guys that's is JUST LIKE running a marathon without bandaids on your boobies *haaa ah* bleeding..fun...!!)
--intermittent fasting (2-4x/wk 18 to 36 hour fasts)
--12-hour fasts (like for the doctor-ordered cholesterol lab testing)
--physical training beyond 40-60min (eg, sex typically does not count)
--low carb diet
--no carb diet
--moderate to high fat diet
--moderate to high protein diet
--Paleo + IF (intermittent fasting) + exercise
Don't confuse ketosis with Type 1 diabetes DKA (diabetic ketoacidosis) which is highly fatal. Many doctors and other healthcare professionals do this. It is like comparing scratching your car with a shopping cart and a 20-car wreck involving multiple fatalities. Ketosis is in fact normal and part of evolution. Humans and other predators up on the food pyramid of life do it all the time. Ketosis is necessary for survival.
The situation known as DKA occurs because the individual has ZERO insulin. Don't worry -- we all make plenty of insulin to 100% prevent this. In fact most people produce far too much insulin which raises blood pressure, causes body fat weight gain, TGs, small dense LDL and other inflammatory markers. Too much insulin also hinders proper muscle development (hard-gainers) with resistance and weight training. (DKA may occur but is VERY very rare in Type 2 diabetes -- unless the person has an infection or sepsis.)
Ketones Fix Our Brain
Altered lipid metabolism in brain injury and disorders.
Adibhatla RM, Hatcher JF.
Subcell Biochem. 2008;49:241-68. Review.
Department of Neurological Surgery, Cardiovascular Research Center, Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI., William S. Middleton Veterans Affairs Hospital, Madison, WI 53792, USA.
Ketogenic Diet Appears to be Neuroprotective For Alzheimer's
The below authors state that "the Ketogenic diet appears neuroprotective, promoting enhanced mitochondrial function and rescuing adenosine triphosphate production" and suggest the value for broad range applications including not just neurovascular conditions but also cancer. We worry about mitochondrial function at TrackYourPlaque (at least I do anyway :) but many others are getting keen to this disorder). Mitochondria are our little nuclear powerhouses that produce our energy currency, e.g. energy packets known as ATP. Mitochondrial dysfunction is what distinguishes many diseases including how gets mercury/aluminum-toxic/brain-damaged from vaccines in children. Read opinions by Seth Roberts PhD HERE (author of the Shangri-La diet, UCB Psychology professor emeritus). Dr.Roberts shares his insightful thoughts and n=1 experiments on brain function and many other topics, including the benefits of probiotics. Many TYP members have tried the SLD (not 'LSD') and lost significant weight with extra light virgin olive oil. It will be very fascinating to see what conclusions will result from examining probiotics. Short-chain saturated fatty acids (SCSFAs: butyrate, propionate, etc) are binders and activators of PPAR-delta, a potent inflammatory and immunomodulatory switch. SCSFAs are produced by anaerobic fermentation and perhaps may be the ingredients that exert the health and longevity benefits of cheese, natto, stinky tofu, yogurt, etc (Nilssen N dissertation ). (interestingly...monounsaturated fatty acids in EVO in fact bind PPAR-delta and other PPAR receptors; ketones=beta-hydroxybutyrate indirectly also activates PPAR-delta).
The ketogenic diet: uses in epilepsy and other neurologic illnesses.
Hartman AL et al. Curr Treat Options Neurol. 2008 Nov;10(6):410-9.
The neuropharmacology of the ketogenic diet.Free article in PMC at journal site
The ketogenic diet and epilepsy.This therapy has been around 80++ yrs.
Progress in neuroprotective strategies for preventing epilepsy.
From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens.
Neuroprotective and disease-modifying effects of the ketogenic diet.
Hartman AL et al. Behav Pharmacol. 2006 Sep;17(5-6):431-9. Review. Free PDF
Why this approach fixes and protects our brain...Cellular mechanisms underlying the neuroprotective activity of the ketogenic diet:
--Reverses damage on energy metabolism
--Reduced glutamate-mediated toxicity
--Normalization effects on γ-aminobutyric acid systems
--Enhances antioxidant mechanisms
--Protects against programmed cell death
--Carb restriction as a protective mechanism and less ROS
Mitochondrial Dysfunction, Heart Disease, and Autism
The Hannah Poling story is quite frankly riveting. This could have been our child. Or your child. After her 19-month vaccination series, Hannah started developing the signs and symptoms for autism, she stopped interacting with her world. Her father being an MD/PhD Neurologist is now trying to find solutions for not only his own daughter's recovery but also a whole legion of children of this Pharma vaccine-generation. Apparently Hannah exhibits a mitochondrial dysfunction which may be one of several factors (likely vitamin ADEK deficiency, wheat/gluten intoxication, omega-6 overdose and omega-3/saturated fatty acid insufficiency are all factors as well, imho, I'm not an autism expert yet).
Subpopulation of Mitochondrial Autism -- Autism Vox Blog
Jon S. Poling, MD, PhD (2006) -- Developmental Regression and Mitochondrial Dysfunction in a Child With Autism. Journal of Child Neurology, Vol. 21, No. 2, 170-172.
Interestingly, Heart Disease is implicated on the 'spectrum' of mitochondrial disorders. A statement from the United Mitochondrial Disease Foundation on the connection between mitochondrial disease and autism: “Recent published reports about the potential links between mitochondrial disorders and autism demonstrate the urgent need for more research into mitochondrial disease, a devastating and often fatal illness. Mitochondrial dysfunction has also been implicated in Alzheimer’s Dementia, Parkinson’s disease, Huntington’s disease, Heart Disease and Diabetes." It is not surprising to me. Individuals with heart disease often present themselves or their children with clinical autism or other conditions on the autistic spectrum: ADD, bipolar, major depression, schizophrenia. Perhaps this conditions are in fact woefully underdiagnosed. Aren't we all a little on the spectrum?
We Are Only As Strong as Our Weakest Mitochrondria
Mitochondria reside in all our alive cells (not hair or nails). They provide the energy needed for all energetic, metabolic and cellular processes. Honestly, if your car had no engine or an improperly functioning engine, how far do you think you will drive? Or at all?
Like our weakest link, sick mitochrondria bring us down.
How do we keep mitochrondria happy? Provide it the fuels it prefers. Give it the parts that need to be replaced upon damage/use. Don't throw cogs in its machinery.
--complex carbs (eg, vegetables)
--lipids (fatty acids: mono-, saturated-, omega-3 long chained pufa, medium chained saturated, etc)
--Coenzyme Q10 (involved in very last stop of ATP production)
--alpha lipoic acid, carnitine
--Vitamin D (incorporated in the phospholipid membranes and prevents lipid peroxidation)
--Avoid toxins: wheat/gluten/grains/x-s-fruit-fructose/legumes/lectins (which GLOM on and/or generate mitochrondria-auto-antibodies), heavy metals (lead, mercury, aluminum, etc), pesticides, synthetic hormones/estrogens/progestins, drugs/pharmaceuticals (eg, statins for MANY), bisphenol, plastics, acrylate (used in enteric-coating of pharmaceuticals, e.g. Costco 'high potency' fish oil)