Benefits/Risks of Insulin
Controlling insulin reaps many rewards. As the previous article suggests , insulin is an ancient hormone ubiquitous in all animals -- from worms to humans -- with classic/nonclassic responsibilities including (see Table 1). Some of these actions are beneficial like thermogenesis, however many of the others are detrimental in the great majority of situations--low potassium
--raised heart rate
--increased uric acid (ie, gout)
--CNS stimulation (ie, anxiety, epression, ADHD)
--prevention of fat from being liberalized for energetic uses
We require only tiny, neglible amounts of insulin for thermogenesis and shuttling of energy (glucose) into muscles and liver for storage.
Damage from Insulin Resistance
In fact, increased energy expenditure is exponentially increased when insulin resistance is kept at bay. What is insulin resistance (IR)? It is like being at a rock concert (or Hannah Montana venue with screaming little girls everywhere) where temporary hearing loss is induced by inclement noise pollution. As soon as the volume returns to a low level, hearing resumes. Shut insulin down by going grain-free, carb-restricted, intermittent fasting and exercising, then inflammatory responses and processes are cut off. The same research demonstrated that men and women have blunted energy expenditure when the 'volume of insulin' is dialed exceptionally high. And for us women, we may even have a 'negative' energy output (in other words 'storage') with energy expenditure during the presence of insulin resistance... Insulin-resistant gals may gain weight with exercise lower rates of energy expenditure... This actually is a common phenomenon and very discouraging for women trying to lose weight and fight an uphill battle as they eat per conventional medical advice 'low fat'/high-carbohydrate/insulin-inducing diets (USDA 'whole grain' pyramidal nonsense).
How To Reduce Insulin Resistance
Degrees of IR can also be effectively cranked down by ( Isharwal S, et al. Dietary nutrients and insulin resistance in urban Asian Indian adolescents and young adults.Ann Nutr Metab. 2008;52(2):145-51.)--normal BMI achievement
--reduction of pro-inflammatory omega-6 oils (nuts, beans, oils from corn soy peanut sunflower)
--increase of anti-inflammatory omega-3 EPA+DHA oils (ie, cod liver, fish oil, pasture-fed milk, meat, eggs, etc)
And of course...wheat avoidance, grain elimination, carb restriction, intermittent fasting and exercise.
Excessive insulin (ie, hyperinsulinemia) leads to the below changes (see below diagram)--inflammation
--generation of TGs and small dense atherogenic LDL
--conversion from fatty streaks to plaque
--increased adipose tissue mass (Obesity, Metablic Syndrome, PCOS )
--accumulation of Triglycerides in non-adipocytes
--nonalcoholic steatohepatitis (fatty liver/NAFLD)
--pancreatic beta-cell failure (fatty pancreas, insulin resistance)
--dilated cardiomyopathy (myocyte (heart cell) stiffening and diastolic dysfunction)
--blood glucose spikes
--expansion of visceral fat (belly fat colonies)
--fatty liver, fatty pancreas, fatty gallbladder, fatty heart
--Diabetes Type 2
--strokes, heart attacks
--cancer (see end)
Lipotoxicity from Excessive Grains and Carbohydrates
Whole human systemic organ functions may become dominated by hyperinsulinemia, leading to all sorts of dysfunction and energy dysregulation. Why rely on primitive petrol... when nuclear power exists? Mitochondria are the powerhouses of ATP, nuclear energy. Excessive carbohydrates shut mitochondria off... and lead to lipotoxicity.
Fig 1. Lipotoxicity in humans originates from excessive release of free fatty acids from hypertrophied adipocytes in obese persons. Organ exposure to high levels of free fatty acids causes lipid droplets to accumulate within the cytosol of nonadipose tissues in proximity to mitochondria (white arrows, bottom).By-products of cytosolic triglyceride accumulation and of lipid metabolism may lead to organ dysfunction and failure. McGavock JM, Victor RG, Unger RH, Szczepaniak LS. Adiposity of the heart, revisited. (Full PDF here .) Ann Intern Med. 2006 Apr 4;144(7):517-24. Review. PMID: 16585666
The inflammation associated with insulin is akin to the oxidative damage that occurs when soft materials like rubber or plastic is left outside exposed to the elements. Over time, the rubber hardens and becomes inelastic and rigid, easily breaking with any shear force. Sort of like running a high-powered hose made out of glass, right? With the elimination of inflammatory influences, human tissues can return to their original soft, elastic, pliable states. This includes endothelium, heart blood vessels, contractile tissues like our heart and skeletal muscles... even our oral gum tissues .
Reversal occurs when insulin is shut down.
The previous review of the research eloquently illustrates the special properties that dictate this ancient 'reactive' hormone. Insulin is one of the few hormones that is controlled by consumed 'substrates'.... What is in charge of turning insulin on and off? What are substrates of insulin?
Food composition directly lowers or raises insulin concentrations. Various other factors of course determine how quick and how sustained hyperinsulinemia occurs (exercise, weight loss, skeletal muscle dominance, size and location of visceral fat colonies (ie, 'belly' is 'bad') but in essence our food controls blood insulin levels.
If what we put in our mouth dictates are insulin levels, then equally powerful is what we don't... In other words, processes like starvation, skipping meals, random eating, intermittent fasting and going low-carb or restricted-carb are ways to reduce and control insulin. Consumption of adequate protein and fats and fiber control insulin release as well.
Consider the complete avoidance of all wheat and grains:
--wheat products (incl cereal, pasta, noodles, bread, crackers, pita, tortilla)
--bulgur (cracked wheat)
--oat (except oat bran)
--corn (incl popcorn, grits, cornmeal, tortilla, chips)
Consume most of the carbohydrates from non-starchy vegetables and raw nuts/seeds and low-GI fruit like berries.
Cancer and the Carbohydrate and Insulin Connection
Controlling insulin not only controls CAD but also controls cancer... Is 'whole grains' just promoting 'whole C-A-N-C-E-R'? As well as 'whole CORONARY ARTERY DISEASE'?
Cancer and Carbs/Insulin References
This is post is a reprise from two years ago... sadly holds true more than ever.
Evolutionary Medicine post Metformin, Insulin Resistance and Cancer