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Chest Pain, SOB, anterior T-wave inversion, positive troponin

Posted Mar 04 2011 9:17am
This 38 yo male presented with chest pain with activity for 4 days, worse on the day of presentation, and associated with SOB.  He has a h/o Renal failure and has a transplant, lately struggling with CMV infection.  His exam was negative.  Here is the ECG
There is sinus rhythm at a rate of about 100 (faster than normal for ACS).  There is T-wave inversion in V1-V3, with some inversion also in lead III.  

The patient had an initial troponin of 0.22 ng/ml and an NT-proBNP of 3200 ng/ml.  He was diagnosed with NSTEMI and admitted to the hospital on heparin.

Kosuge et al. showed that, when T-waves are inverted in precordial leads, if they are also inverted in lead III and V1, then pulmonary embolism is far more likely.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T10-4MY0S1Y-3&_user=7692415&_coverDate=03%2F15%2F2007&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_searchStrId=1665055033&_rerunOrigin=scholar.google&_acct=C000072572&_version=1&_urlVersion=0&_userid=7692415&md5=adc9bc1668f09fddceb8e0c5756aad78&searchtype=a
In this study, "negative T waves in leads III and V1 were observed in only 1% of patients with ACS compared with 88% of patients with APE (p <0.001). The sensitivity, specificity, positive predictive value, and negative predictive value of this finding for the diagnosis of APE were 88%, 99%, 97%, and 95%, respectively. In conclusion, the presence of negative T waves in both leads III and V1 allows APE to be differentiated simply but accurately from ACS in patients with negative T waves in the precordial leads."

Later, the patient had an echocardiogram which showed hyperdynamic LV fct (EF = 80%) and a dilated RV.  PE was diagnosed by CT, with bilateral pulmonary emboli.

If this were ACS, it would be Wellens' syndrome, and this just does not look like Wellens' (difficult for me to explain why, but compare with other Wellens' cases on this blog).

Compare with a classic Wellens' with biphasic T's
http://1.bp.blogspot.com/_BCuKCPlE6DY/SRjCo3tzEQI/AAAAAAAAAC4/PBX4Tzxyf1w/s1600-h/ecg4b.jpg

Anterior T-wave inversion, when accompanied by T-wave inversion in lead III, especially if tachycardic, should make you think of PE.  A simple emergency physician performed bedside ultrasound would have confirmed this.  Troponin will not help you in this diagnosis because, when there are T-wave inversions (in my experience), the troponin is positive.  (This would make a good study).
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