Pharmacological approaches to improve endothelial repair mechanisms. Besler C, Doerries C, Giannotti G, Lüscher TF, Landmesser U. Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland.
Endothelial injury is thought to play a pivotal role in the development and progression of vascular diseases, such as atherosclerosis, hypertension or restenosis, as well as their complications, including myocardial infarction or stroke. Accumulating evidence suggests that bone marrow-derived endothelial progenitor cells (EPCs) promote endothelial repair and contribute to ischemia-induced neovascularization. Coronary artery disease and its risk factors, such as diabetes, hypercholesterolemia, hypertension and smoking, are associated with a reduced number and impaired functional activity of circulating EPCs. Moreover, initial data suggest that reduced EPC levels are associated with endothelial dysfunction and an increased risk of cardiovascular events, compatible with the concept that impaired EPC-mediated vascular repair promotes progression of vascular disease. In this review we summarize recent data on the effects of pharmacological agents on mobilization and functional activity of EPCs. In particular, several experimental and clinical studies have suggested that statins, angiotensin-converting enzyme inhibitors, angiotensin II type 1 receptor blockers, PPAR-gamma agonists and erythropoietin increase the number and functional activity of EPCs. The underlying mechanisms remain largely to be defined; however, they likely include activation of the PI3-kinase/Akt pathway and endothelial nitric oxide synthase, as well as inhibition of NAD(P)H oxidase activity of progenitor cells.
The above seminal article suggests that bone marrow may hold the key to improving endothelial problems and inflammation. The astute authors suggest the below would be helpful. What are the food components if we had to 'deconstruct' the pharmaceutical analogues listed above? Would food be safer? Better? More efficacious? Yes... I belive so. --statins (how about fish oil? how about veggie-fibers? how about chol/sat fats?) --angiotensin-converting enzyme inhibitors (how about Taurine?) --angiotensin II type 1 receptor blockers (how about Taurine?) --PPAR-gamma agonists (how about high dose EPA DHA fish oil? ALA/flaxseed oil? how about Taurine/Leucine proteins? how about exercise/ IF/ starving occasionally? sat fats? how about meat-derived Carotenoids which synergize PPAR effects? how about Lutein/eggs? Astaxanthin? Krill oil?) --erythropoietin (how about eating bonemarrow?)
What does Bone Marrow contain which is so nutrient dense and fabulously fantastic? --EPA + DHA --Hormones: testosterone, estrogen, hGH --Vitamin A D E K --EPO (erythropoiten) --Minerals: Magnesium, Phosphorous, Calcium, Zinc, etc --Saturated Fats --EPCs (endothelial progenitor cells) which improve our BLOOD VESSELS and promote better CIRCULATION AND BLOOD FLOW and healthier endothelium
Wow. My cat who can eat whole mice and their bones knows what she's doing!