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Testosterone & Women's Brain Function

Posted Jun 24 2013 3:00am
It's been said that hormonal young men w/high levels of testosterone are constantly thinking about sex.  Certainly, as we age, our libido decreases.  Whether this is a result of a natural decline in testosterone or of cognitive maturity is open to debate.  It's also been reported that hypogonadal men are more depressed & perhaps not as sharp cognitively speaking.  Some studies even show a benefit to testosterone replacement in such men w/low T.

But what about women?  Well, my disclaimer is that the following info has not been published in a peer reviewed journal but rather was  presented at last week's meeting of endocrinologists .  The authors randomized 92 healthy postmenopausal women avg 60yo who had both normal cognitive function and as well, had not taken any systemic hormone therapy, to 0.22g of testosterone as a transdermal gel or to a placebo for 26wks.  

The authors noted that while these postmenopausal women were cognitively intact, those randomized to T still scored statistically significantly better than those who received placebo.  The improvement was coincident to an increase in testosterone level from low normal to mid-normal range.  Luckily, there were no negative outcomes in this small short study.  If you can't wait, ask your doc about this way off-label use of T.  But just to be on the safe side, wait if you can afford to do so.

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