Health knowledge made personal
1 Comment
|
Increasing the bioavailability of resveratrol by way of oral consumption in liquid form. Resveratrol is rapidly metabolized by humans which makes for little absorption into our blood stream in it's basic trans form. In hopes to determine a better way to maximize bioavailability many have tried the following methods: Transdermal Delivery: this method works by applying resveratrol directly to the skin via a lotion (cream) or by using a transdermal patch. The patch is becoming a very popular way to deliver medications. Most commonly used for the Nicotine Patch, it is also used for many other drugs. Micronizing Resveratrol Particle Size: this is the act of refining the standard particle size of resveratrol to a much smaller size of under 10 microns (10um). In previous studies micronization of drugs improved both bioavailability and clinical efficacy. Solution Mixed Delivery Systems: adding substances such as Tween 80 (also known as polysorbate 80), Quercetin, or Alcohol in a pre-mixed liquid or powder capsule form. Some studies have shown these methods increase absorption. This leads us to the delivery method called Buccal Mucosa. Inside our mouths, and primarily on our cheek walls, we have mucous membranes. These membranes provide an absorption point for many different substances. A recent study completed by researchers at the University of Queensland in Australia that will be published this upcoming September in, " Alcoholism: Clinical & Experimental Research," discussed the absorption potentials of resveratrol from red wine consumption. In a report on the research by Forbes Magazine, professor Stephen Taylor states, " Most of the resveratrol in imbibed red wine does not reach the circulation." Further, " Interestingly, absorption via the mucous membranes in the mouth can result in up to around 100 times the blood levels, if done slowly rather than simply gulping it down." While this study uses Red Wine which contains much lower doses of resveratrol compared to that of pure supplements, it shows the potential benefits of the buccal delivery method. Some questions have been raised throughout the research community whether or not there is sufficient surface area in the mouth to absorb large enough amounts of resveratrol. This also brings up the controversial topic of resveratrol dosage. How much do we really need? These questions will need to be answered to confirm buccal absorption as an improved method of delivering resveratrol into our blood stream. Live Longer, Markus Related Articles: Resveratrol Dosage: The Million Dollar Question! Resveratrol Scam: Warning and Consumer Alert! |
Write a comment:
|
