Ignored long enough, this pain can lead to diabetic ulcers and can take a tremendous toll on the patient in terms of lost productivity as well as medical costs of evaluation, treatment & even hospitalization. So it's welcome news that a case-control study was published in the September issue of the American Journal of Pharmacy Benefits in which the authors noted that regular consumption of L-methylfolate combination therapy was associated w/lower all-cause hospitalization as well as lower disease-related costs.
The authors arrived at their conclusion by comparing 814 patients w/diabetic neuropathy prescribed L-methylfolate combination vs 814 matched controls not prescribed L-methylfolate combination therapy. Before you jump out of your chair and call your family doc or ask your local pharmacist about this medical food, know that the manufacturer sponsored the study and one of the authors worked for a research team that has a relationship with the funder. None of this should disqualify the study, but it obviously affects your interpretation if you're especially cautious & cynical like me. In the meantime, as we await an NIH sponsored randomized controlled trial, I think the benefit of avoiding a hospital stay overrides the risk of any potential side effect from these vitamins.