This last point is one of vindication for me & many others as we thought it odd that while the E+P arm of Women's Health Initiative was linked to breast cancer & the E only arm wasn't, all the blame for breast cancer was laid at the feet of E.
And yet we see this same rush to judg(e)ment with the recent HPS2-THRIVE study in which niacin+laropiprant was compared to placebo rather than to niacin and yet niacin was blamed for the bad outcome , rather than positing that perhaps this novel agent, laropiprant was the cause. Don't get me wrong. I'm not saying that niacin is a great drug but rather that we can't blame it alone for bad outcomes when the study didn't compare it alone to placebo, but rather it in combination w/an unknown drug to placebo.
Stay tuned for Part 3 of this look at the Global Consensus Statement on menopausal hormone therapy .
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