So here it is nearly a decade later and a study was released last week in JAMA concluding that almost 6 years use of CEE alone did not change (increase or decrease) heart disease, stroke risk, venous thromboembolism risk, colorectal cancer or total (all-cause) mortality. Interestingly, those who took CEE alone did demonstrate a lower risk of breast cancer as noted in the initial study.
But what do you do if your patient doesn't believe in Big Pharma products (and you don't believe in compounded estradiol)? Consider branded bio-identical transdermal estradiol products such as Vivelle-Dot or Climara (not Climara Pro which contains non-bio-identical levonorgestrel). That way you and your patient can have the best of both worlds.