nested case-control analysis of a retrospective cohort study published early online last week in JAMA Internal Medicine , the authors noted that new use of long-acting beta agonists and anticholinergics in older patients with chronic obstructive pulmonary disease was associated with an increase in cardiovascular events. The authors arrived at their conclusion by finding 191,005 patients w/COPD and compared those who'd recently been prescribed a LABA and/or LAA to controls who were not prescribed either medication. The former were more likely to be hospitalized for a cardiovascular event soon after starting their LABA +/- LAA. Of note, all were older than 65yo.In a
So, what does this mean for you & me? First, we can't live w/o our heart. Second, we can't live w/o our lungs. Duh, right? But the fact remains that taking medications considered standard of care for COPD has just been linked to an increase in heart disease events. Granted this study doesn't prove cause & effect. However, it does raise some grave concerns. At the very least, we need to monitor our patients more closely. And until more evidence is published, we'll need to include cardiovascular events in our discussion regarding new use of LABAs & LAAs.
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