in February 2010, a prospective cohort study was published in Diabetes Care in which 1,353 diabetics avg 68yo were followed for close to a decade on average. Using statistics way above my pay grade, the authors concluded that all-cause mortality was more than twice that of non-diabetics. This also applied to cardiovascular mortality while cancer mortality was just 45% greater.Then
Of note, the rate of cancer deaths was 62% greater in those diabetics who did not use metformin compared to non-diabetics but was actually 12% less (statistically non-significant) in those diabetics who took metformin compared to non-diabetics. Did that make sense? While diabetes increases one's risk of death from any cause, heart disease & cancer when compared to non-diabetes, use of metformin was associated w/lower risk of cancer deaths compared to not using the biguanide. Looks like we have the start of a trend here!