longitudinal prospective population-based study was published 4 years ago in JAMA Internal Medicine looking at the effect of ACE inhibitors with regards to Alzheimer's disease. Taken as a whole, there was no link. But if you looked at just the centrally acting ACE inhibitors, their use was linked to a lower rate of cognitive decline, more so than when compared to noncentrally acting ACE inhibitors. Which brings me to an observational case-control study published last week/month in BMJ Open in which centrally acting ACE inhibitors were linked to improvement in cognition & reduction in cognitive decline. The authors made their conclusion after following for six months 361 patients w/Alzheimer's disease, of whom 85 received a centrally acting ACE inhibitor while 276 did not.Interestingly enough, a
So if you need to take blood pressure medication(s), one of which is an ACE inhibitor, I'm sure you're curious which ones cross the blood-brain barrier: captopril, fosinopril, lisinopril, perindopril, ramipril & trandolapril. On the other hand, benazepril, enalapril, moexipril & quinapril do not. The good news for you & me is that captopril & lisinopril are available for $4/mo at WalMart and its competitors .
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