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Fish Oil vs Bleeding Risk

Posted Jan 06 2012 3:01am
Fish, fish, fish.  That's just about all you hear these days.  Eat more fish.  Take your fish oil.  Why?  It's been associated with lower risk of heart disease, stroke & cognitive loss, among other chronic conditions.  However, one of the proposed methods by which fish oil works is by inhibiting platelet function in some fashion, the idea being that less clotting allows for more blood flow.

But remember that double-edged sword?  Blood clots are an example of this.  For instance, if you cut yourself in the kitchen or in your workshop, you want to stop bleeding quickly.  Same if you nick yourself while shaving.  Nosebleeds, too.  And you can envision menstrual flow as controlled bleeding.  But what if you can't form clots?  Hemophilia is a generic term for just such a condition in which the above examples can turn deadly.

Controlled bleeding also comes into play during surgeries and procedures.  Your surgeon doesn't want you bleeding into his operating field.  Yet you need to continue to perfuse your organs.  Often times as part of our pre-operative evaluation, surgical candidates are advised to stop taking aspirin, vitamin E, ginkgo biloba, and even fish oil several days, if not weeks, prior to the proposed surgery date.  The idea is to minimize one's risk of oozing.
Well, in a cohort study published this month of 1523 patients admitted for acute myocardial infarction, fish oil was not associated with an increase risk of bleeding as might be expected given the thrombolytic therapy administered.  Importantly, red blood cell levels of fish oil demonstrated no correlation to bleeding events.  The authors chose to measure fish oil level directly rather than assess reported consumption which is subject to recall bias and supplement manufacturing variance.
The good news for you & me is that we can and should continue to take our fish oil and eat our fish without worry for bleeding out.  So go enjoy some fish for dinner tonight.

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