With that said, varenicline does help smokers quit smoking. But so does bupropion and replacement nicotine without increasing cardiovascular risk (and without increasing suicide risk, yet another strike against varenicline). But as I mentioned yesterday, don't stop taking any meds abruptly. Instead, discuss your options w/your family physician.
And don't forget to consider relative risk vs absolute risk. While those who received varenicline had approximately twice the risk of heart attacks, etc, the absolute risk was only 4 more per ~350 (from 3/350 to 7/353). Therefore, the number needed to harm (NNH) is 100. In other words, 100 smokers would have to take varenicline for one year for one to have a cardiovascular event. You should compare that number to your risk for a heart attack (see both Framingham & Reynolds Risk ).