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DrSears.com | Ask Dr. Sears

Posted Oct 01 2008 8:38pm
CLA, omega 3 and weight reduction

Q. I have been on the anti-depressant Paxil for the last eight years. Recently I made a decision to get off Paxil and visited a psychiatrist for consultation and supervision in weaning myself. Today is my first day without Paxil totally. My question relates to the weight gain that has been associated with anti- depressants. I'm a former competitive distance runner and have continued to exercise regularly six to seven days a week. Despite my exercise, my weight ballooned from 180 to as much as 220 at one time. I have started the Zone Diet but also read an article about weight loss after coming off anti-depressants. The author recommended omega 3 and CLA to help with the weight reduction along with diet and exercise. His suggestion was six tablets of Omega 3 (three in the morning and three just before lunch) and three CLA tablets (one with each Omega 3 dosage and one about 3-4 p.m. What is your opinion as to the benefits of CLA and Omega 3 in helping with weight loss? I'm a 52-year-old non-smoking male with no health issues other than the general anxiety disorder. There is a history of diabetes on my father's side, but as of yet I show no signs except my most recent blood test showed high cholesterol, which caused me to make the decision to get off the Paxil and get my diet under control along with my regular exercise of light weights and running.

A. Anti-depressants such as Paxil increase serotonin, but unfortunately decrease dopamine. This is what leads to the weight gain. I would not recommend CLA since it increases insulin resistance (the underlying cause of diabetes) in humans and causes fatty livers in animals. However, I would strongly recommend EPA and DHA because the combination will increase both serotonin and dopamine. The amount that you would need is between 7.5 and 10 grams per day. As a side benefit, you will see your athletic performance significantly improve."

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