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Canine Seizure Control Update - Using New Prescription (Zonisamide) for Our Siberian Husky

Posted Aug 12 2009 10:52pm 2 Comments

Our Siberian Husky has had Grand Mal Seizures for the past three years.  They started in 2006 and he is 9 years old.  We could not find any diagnosis other than Idiopathic Epilepsy.

For the most part the prescription for Phenobarbital has controlled the seizure activity.  He would have one or two a year and we would adjust the medication.

In April of this year he started having multiple seizures frequently.  We increased the meds again and it did not help control them.

I have thoroughly researched everything known to man about this topic, possible causes, any and all name it.  I have adjusted his diet and started giving him natural supplements and vitamins as well.

After 8 seizures since April of this year we went to see a Vet Neurologist.  I cannot tell you how much I love this new doctor.  I went in armed with huge amounts of info and a lot of questions.  She was impressed with my plethora of information and logs and I was impressed with her knowledge, compassion, and her generosity with her time in speaking with me.  She prescribed a new drug that I, too, was also interested in trying for our puppy - after reviewing the studies and comparing ongoing symptoms and observations in our Husky.

We started the new drug, Zonisamide, in conjunction with the current phenobarbital regimen and also added some more "Liver Protecting" natural supplements.  We started the Zonisamide on a half-dose of what would be recommended for our dog's size.  This was, in part, due to my reluctance on the "side-effect" period.

In April of this year our regular Vet prescribed Potassium Bromide - with no help.  The Potassium Bromide caused a host of horrible side-effects and I took him off the meds within a week.  The Bromide made him very ataxic (weak, wobbly legs) and gave him tremors that were like seeing someone with progressive Parkinson's Disease.

So, the Vet Neurologist agreed that we would try a half-dose of the Zonisamide and keep the Phenobarbital the same and watch and wait.  She said that after a while on this therapy, considering its' effectiveness, that we could start to decrease the Phenobarbital and increase the Zonisamide.  The Zonisamide is supposed to have fewer side-effects and be less harmful to Liver function.

So far he is doing well.  I am so very thankful and appreciative of this new therapy.  If you've ever dealt with Canine Grand Mal Seizures on a consistent know that controlling and minimizing the seizure activity is truly a God-send.

I feel completely and totally blessed to have found such a wonderful Vet Neurologist to assist us in taking care of our Husky.  We are hopeful and optimistic that this new therapy is well-suited for our beloved pet. :)
Comments (2)
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I have a Husky too with epilepsy! I started the medication 100 mg Pheno + 600 mg KBr per day, and it was very good, cause she have no seizure for a year. But, unfortunatelly, she started a few month ago to have cluster seizures.  Is anyone who can help me with some advises? My email Thanks in advance

I have a Husky that had 10 grand seizures one day a year ago without any leading up to it.  She was at the pet hospital for three days and then I started her on Phenobarbitol and she has only had one minor one since then.  I'm hoping it controls it for a long time.  I didn't know that Husky dogs were prone to epilepsy.  It's weird because the day she had all the seizures was the only time that my husband and I had left her for a weekend.  My daughter came home to doggy sit and I think she had separation anxiety that brought it on.  Could that be possible? 


Nancy D.

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