beta blockers in general don't make a hill of beans with regards to heart disease & risk factors . In a comparative analysis published earlier this week in the Archives of Internal Medicine , the authors followed 120,978 hypertensive individuals (over 91% of whom were taking atenolol vs 9% on metoprolol tartrate) of which 11,176 atenolol users were matched to the same number of metoprolol tartrate users. It should be noted that there are actually two forms of metoprolol, the twice daily tartrate form studied here and the once daily succinate form, compared to once daily atenolol.So back to drugs. Yesterday, we noted that
After following these participants for over 5 years, the authors concluded that there was no difference in the rate of new cardiovascular events, eg heart attack, heart failure & stroke, between use of these two beta blockers. But if you ask me, it's a lot easier to take medicine once daily rather than twice daily. Of course, this study does nothing to address the use of carvedilol & nebivolol.