FDA just announced today concurrence of a possible link between pioglitazone and bladder cancer based upon the same data. But as with all observational data that is re-analyzed, this only offers an association but no proof of causation. Thus, while the greatest risk of bladder cancer was noted in those who'd taken pioglitazone for at least 2-3 years, the FDA cautiously added a warning for use greater than 1 year to all product labels.So perhaps it should come as no surprise that our own
What's this mean for you & me? Before you abruptly stop taking pioglitazone, talk w/your family physician (as always). What other options do you have? What's your personal risk for bladder cancer? If you've had environmental exposure to several compounds associated w/bladder cancer, you might want to consider switching. Certainly, bloody urine needs further evaluation, especially if it's painless in a smoker. And in the end, focus on nutrition & exercise as ideal & free risk-free solution to diabetes.
By the way, thank goodness for complimentary WiFi inside the Vancouver International Airport (YVR)!