The following is an email from David Benic of Dr Vitamin Solutions, an online seller of LEF products. He wrote me a while back that he was taking the product himself, and I checked in with him the other day as to how it was going.
Here’s his response, as well as an email response to him from Life Extension. He gave me permission to publish this in it’s entirety. - LCC
Hello LCC. I have lost 7 pounds so far. Not as much as I have hoped, but better than nothing. I don’t have my doctor appt until January for the blood work, but I will let you know then. In working with the Life Extension doctors, here is all the research I can muster up on Integra Lean. I hope this can clear up many of the questions & concerns you have. Thanks for checking in!
Unpublished Study – Abstract(this abstract can be sent but we can not release the full study until it is published). This is the study referencing the 28lbs in 10 weeks and we discussed the highlights of this study in the SuperSale 2008 magazine.
IMPORTANT POINT
This impressive clinical data was reviewed, evaluated, and validated by the scientific panel associated with the 5 th International Conference on Functional Foods for Chronic Diseases, and Dr. Oben was then granted approval for scientific conference presentation on October 17 th, 2008.
The scientific panel:
http://www.functionalfoodscenter.net/1486177.html
The conference program:
http://www.functionalfoodscenter.net/Conference_Program.html
11:15-12:15 p.m. | The Potential Use of an Extract of Irvingia Gabonensis in the Management of Obesity and Metabolic Syndrome in Cameroon
Dr. Julius E Oben, Professor, Head of Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Science, University of Yaounde, Cameroon |
Abstract
The use of Irvingia gabonensis extract (IGOB131) in the management of metabolic syndrome in Cameroon
Judith L Ngondi, Rosane Matsinkou and Julius E Oben*
Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry,
BP 812, Faculty of Science, University of Yaounde I, Cameroon.
Aim:Metabolic syndrome, like many other obesity-related conditions, is on the rise in Cameroon and other parts of the world. The purpose of this study is to assess the possibility of IGOB131, an extract of the West African plant, Irvingia gabonensis, as a treatment for metabolic syndrome.
Methods:The study was a 10 week, randomized, double-blind, placebo-controlled design involving 102 healthy, overweight and obese participants (53% male, 47% female, ages 19–50; mean age = 34). The subjects were randomly divided into two equal groups—placebo and IGOB131 treatment, and all received one 150 mg capsule containing placebo or extract twice a day before meals. A total of 9 anthropomorphic and serological measurements were taken at baseline and at 4, 8, and 10 weeks.
Results:Compared to the placebo group, the IGOB131 group showed a statistically significant different on all 9 variables by week 10. These included the three anthropomorphic variables (body weight, body fat, waist size) and the 6 measures of serological levels (plasma total cholesterol, LDL cholesterol, blood glucose, C-reactive protein, adiponectin, and leptin).
Conclusion:Serum leptin levels were lower in the IGOB131 group while their serum adiponectin level was higher. These results, combined with those on the other 7 variables, suggest that the Irvingia gabonensis extract, IGOB131, may be used to manage metabolic syndrome through control of obesity and lipid profile.
Published studies(Indexed on PubMed)
There are several published studies on Irvingia, a few of which have the full text article for free via PubMed. Ctrl + click to go right to the abstract on PubMed.
Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and Leptin genes and up-regulation of the adiponectin gene.
Oben JE, Ngondi JL, Blum K.
Lipids Health Dis. 2008 Nov 13;7:44.
Note:Kenneth Blum is from the Department of Physiology & Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. This is especially important for customers who want to see US studies.
“RESULTS: The IGOB131 significantly inhibited adipogenesis in adipocytes.The effect appears to be mediated through the down-regulated expression of adipogenic transcription factors (PPAR gamma) [P less than 0.05] and adipocyte-specific proteins (leptin) [P less than 0.05], and by up-regulated expression of adiponectin [P less than 0.05]. CONCLUSION: IGOB131 may play an important multifaceted role in the control of adipogenesis and have further implications in in-vivo anti obesity effects by targeting the PPAR gamma gene, a known contributory factor to obesity in humans.”
The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study.
Oben JE, Ngondi JL, Momo CN, Agbor GA, Sobgui CS.
Lipids Health Dis. 2008 Mar 31;7:12.
The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon.
Ngondi JL, Oben JE, Minka SR.
Lipids Health Dis. 2005 May 25;4:12.
Note:this study used a crude extract so the dosage was higher than the most recent study which used a much more concentrated 2 nd generation extract that allowed for similar effects but at a significant lower dosage (since it is more potent).
Phytochemical and antimicrobial activities of the wild mango-Irvingia gabonensis extracts and fractions.
Fadare DA, Ajaiyeoba EO.
Afr J Med Med Sci. 2008 Jun;37(2):119-24.
Effect of aqueous leaf extract of Irvingia gabonensis on gastrointestinal tract in rodents.
Abdulrahman F, Inyang IS, Abbah J, Binda L, Amos S, Gamaniel K.
Indian J Exp Biol. 2004 Aug;42(8):787-91.
Antioxidant capacity of some herbs/spices from cameroon: a comparative study of two methods.
Agbor GA, Oben JE, Ngogang JY, Xinxing C, Vinson JA.
J Agric Food Chem. 2005 Aug 24;53(17):6819-24.
Note: “Irvingia gabonensis tops the FRAP free antioxidant list…”
Additional Published Studies
The following are additional published studies on Irvingia in peer reviewed journals – but these are not indexed on PubMed so they will not show up on a PubMed search. These two are preclinical studies on Irvingia.
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 4, 2006, pp. 94-101
GLYCAEMIC VARIATIONS AFTER ADMINISTRATION OF IRVINGIA GABONENSIS SEEDS FRACTIONS IN NORMOGLYCEMIC RATS
Judith Laure Ngondi , Zephyrin Fossouo, Emile Joachim Djiotsa, Julius Oben
Department of Biochemistry, P.O. BOX 812, Faculty of Science, University of Yaounde I, Cameroon. Email: jlngondi@yahoo.com, Tel: +237 767 13 75, Fax:+237 220 83 56
Abstract(Full Text - http://www.bioline.org.br/request?tc06056 )
The action of Irvingia gabonensis seed fractions in reducing or slowing down the intestinal absorption of glucose was evaluated in normoglycaemic rats. The crude seeds (CS), the defatted seeds (DS) and the protein fraction (PF) were administered at dose of 400mg/ kg body weight to normoglycemic rats submitted to oral glucose test (OGTT) with glucose (2g/kg body weight). The results obtained show a significant reduction of the postprandial glucose level after a glucose load of (2g/kg body weight) as well as fasting blood glucose levels with the three fractions.
Afr. J. Trad.CAM(2006) 3 (4): 74 – 77
GABONENSIS SEEDS ON STREPTOZOTOCIN DIABETIC RATS.
Judith Laure Ngondi , Emile Joachim Djiotsa, Zephyrin Fossouo, Julius Oben
Department of Biochemistry, P.O. BOX 812, Faculty of Science, University of Yaounde I, Cameroon.
Abstract
The hypoglycaemic effect of the methanol extract of Irvingia gabonensis seeds (Irvingiaceae) was examined in streptozotocin-diabetic rats. A single oral administration of the methanol extract at doses of 150 and 250mg/kg significantly (P < 0.001) lowered the plasma glucose levels in diabetic rats two hours after treatment.
Journal of Food Technology3 (4): 592-594, 2005 (Africa)
Effect of Irvingia gabonensis Kernel Oil on Blood and Liver Lipids on Lean and Overweight Rats
Ngondi Judith L, Mbouobda Hermann D, S. Etame and Oben Julius
Many studies suggest oils with a high medium chain saturated fatty acids content are responsible for the cholesterol-raising effect of saturated fat The aim of this study was to evaluate the effect of the Irvingia gabonensis kernel oil on plasma lipoproteins, blood glucose and liver lipids in rats. A feeding experiment was carried out in which rats were fed to a normal diet and the received a daily administration of oil 1 mL of Irvingia oil or desionised water water (controls). After 4 weeks, blood lipids, blood glucose liver and fecal lipids were mesured using standard methods. After 4 weeks the plasma HDL cholesterol (p<0.01) and triglyceride levels (0.01) were higher in Irvingia oil group. There was no difference in plasma cholesterol and LDL cholesterol level but LDL:HDL and total cholesterol:HDL ratios (p<0.01) were significantly lower after the administration of the Irvingia oil. The Blood glucose level (p<0.01) of animals receiving Irvingia oil was also lower compare to controls. The liver cholesterol (p<0.01) and triglyceride levels (P<0.002) were significantly higher in Irvingia oil group. Although the Irvingia oil has a myristic acid and lauric acid values of 39.2 and 51.1%, respectively, the hypocholesterolemic effect can be explain by high the Vitamin A, $- carotene and may be phytosterols levels.
The following is an email from David Benic of Dr Vitamin Solutions, an online seller of LEF products. He wrote me a while back that he was taking the product himself, and I checked in with him the other day as to how it was going.
Here’s his response, as well as an email response to him from Life Extension. He gave me permission to publish this in it’s entirety. - LCC
Hello LCC. I have lost 7 pounds so far. Not as much as I have hoped, but better than nothing. I don’t have my doctor appt until January for the blood work, but I will let you know then. In working with the Life Extension doctors, here is all the research I can muster up on Integra Lean. I hope this can clear up many of the questions & concerns you have. Thanks for checking in!
Unpublished Study – Abstract(this abstract can be sent but we can not release the full study until it is published). This is the study referencing the 28lbs in 10 weeks and we discussed the highlights of this study in the SuperSale 2008 magazine.
IMPORTANT POINT
This impressive clinical data was reviewed, evaluated, and validated by the scientific panel associated with the 5 th International Conference on Functional Foods for Chronic Diseases, and Dr. Oben was then granted approval for scientific conference presentation on October 17 th, 2008.
The scientific panel:
http://www.functionalfoodscenter.net/1486177.html
The conference program:
http://www.functionalfoodscenter.net/Conference_Program.html
11:15-12:15 p.m.
Dr. Julius E Oben, Professor, Head of Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Science, University of Yaounde, Cameroon
Abstract
The use of Irvingia gabonensis extract (IGOB131) in the management of metabolic syndrome in Cameroon
Judith L Ngondi, Rosane Matsinkou and Julius E Oben*
Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry,
BP 812, Faculty of Science, University of Yaounde I, Cameroon.
Aim:Metabolic syndrome, like many other obesity-related conditions, is on the rise in Cameroon and other parts of the world. The purpose of this study is to assess the possibility of IGOB131, an extract of the West African plant, Irvingia gabonensis, as a treatment for metabolic syndrome.
Methods:The study was a 10 week, randomized, double-blind, placebo-controlled design involving 102 healthy, overweight and obese participants (53% male, 47% female, ages 19–50; mean age = 34). The subjects were randomly divided into two equal groups—placebo and IGOB131 treatment, and all received one 150 mg capsule containing placebo or extract twice a day before meals. A total of 9 anthropomorphic and serological measurements were taken at baseline and at 4, 8, and 10 weeks.
Results:Compared to the placebo group, the IGOB131 group showed a statistically significant different on all 9 variables by week 10. These included the three anthropomorphic variables (body weight, body fat, waist size) and the 6 measures of serological levels (plasma total cholesterol, LDL cholesterol, blood glucose, C-reactive protein, adiponectin, and leptin).
Conclusion:Serum leptin levels were lower in the IGOB131 group while their serum adiponectin level was higher. These results, combined with those on the other 7 variables, suggest that the Irvingia gabonensis extract, IGOB131, may be used to manage metabolic syndrome through control of obesity and lipid profile.
Published studies(Indexed on PubMed)
There are several published studies on Irvingia, a few of which have the full text article for free via PubMed. Ctrl + click to go right to the abstract on PubMed.
Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and Leptin genes and up-regulation of the adiponectin gene.
Oben JE, Ngondi JL, Blum K.
Lipids Health Dis. 2008 Nov 13;7:44.
Note:Kenneth Blum is from the Department of Physiology & Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. This is especially important for customers who want to see US studies.
“RESULTS: The IGOB131 significantly inhibited adipogenesis in adipocytes.The effect appears to be mediated through the down-regulated expression of adipogenic transcription factors (PPAR gamma) [P less than 0.05] and adipocyte-specific proteins (leptin) [P less than 0.05], and by up-regulated expression of adiponectin [P less than 0.05]. CONCLUSION: IGOB131 may play an important multifaceted role in the control of adipogenesis and have further implications in in-vivo anti obesity effects by targeting the PPAR gamma gene, a known contributory factor to obesity in humans.”
The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study.
Oben JE, Ngondi JL, Momo CN, Agbor GA, Sobgui CS.
Lipids Health Dis. 2008 Mar 31;7:12.
The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon.
Ngondi JL, Oben JE, Minka SR.
Lipids Health Dis. 2005 May 25;4:12.
Note:this study used a crude extract so the dosage was higher than the most recent study which used a much more concentrated 2 nd generation extract that allowed for similar effects but at a significant lower dosage (since it is more potent).
Phytochemical and antimicrobial activities of the wild mango-Irvingia gabonensis extracts and fractions.
Fadare DA, Ajaiyeoba EO.
Afr J Med Med Sci. 2008 Jun;37(2):119-24.
Effect of aqueous leaf extract of Irvingia gabonensis on gastrointestinal tract in rodents.
Abdulrahman F, Inyang IS, Abbah J, Binda L, Amos S, Gamaniel K.
Indian J Exp Biol. 2004 Aug;42(8):787-91.
Antioxidant capacity of some herbs/spices from cameroon: a comparative study of two methods.
Agbor GA, Oben JE, Ngogang JY, Xinxing C, Vinson JA.
J Agric Food Chem. 2005 Aug 24;53(17):6819-24.
Note: “Irvingia gabonensis tops the FRAP free antioxidant list…”
Additional Published Studies
The following are additional published studies on Irvingia in peer reviewed journals – but these are not indexed on PubMed so they will not show up on a PubMed search. These two are preclinical studies on Irvingia.
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 4, 2006, pp. 94-101
GLYCAEMIC VARIATIONS AFTER ADMINISTRATION OF IRVINGIA GABONENSIS SEEDS FRACTIONS IN NORMOGLYCEMIC RATS
Judith Laure Ngondi , Zephyrin Fossouo, Emile Joachim Djiotsa, Julius Oben
Department of Biochemistry, P.O. BOX 812, Faculty of Science, University of Yaounde I, Cameroon. Email: jlngondi@yahoo.com, Tel: +237 767 13 75, Fax:+237 220 83 56
Abstract(Full Text - http://www.bioline.org.br/request?tc06056 )
The action of Irvingia gabonensis seed fractions in reducing or slowing down the intestinal absorption of glucose was evaluated in normoglycaemic rats. The crude seeds (CS), the defatted seeds (DS) and the protein fraction (PF) were administered at dose of 400mg/ kg body weight to normoglycemic rats submitted to oral glucose test (OGTT) with glucose (2g/kg body weight). The results obtained show a significant reduction of the postprandial glucose level after a glucose load of (2g/kg body weight) as well as fasting blood glucose levels with the three fractions.
Afr. J. Trad.CAM(2006) 3 (4): 74 – 77
GABONENSIS SEEDS ON STREPTOZOTOCIN DIABETIC RATS.
Judith Laure Ngondi , Emile Joachim Djiotsa, Zephyrin Fossouo, Julius Oben
Department of Biochemistry, P.O. BOX 812, Faculty of Science, University of Yaounde I, Cameroon.
Abstract
The hypoglycaemic effect of the methanol extract of Irvingia gabonensis seeds (Irvingiaceae) was examined in streptozotocin-diabetic rats. A single oral administration of the methanol extract at doses of 150 and 250mg/kg significantly (P < 0.001) lowered the plasma glucose levels in diabetic rats two hours after treatment.
Journal of Food Technology3 (4): 592-594, 2005 (Africa)
Effect of Irvingia gabonensis Kernel Oil on Blood and Liver Lipids on Lean and Overweight Rats
Ngondi Judith L, Mbouobda Hermann D, S. Etame and Oben Julius
Many studies suggest oils with a high medium chain saturated fatty acids content are responsible for the cholesterol-raising effect of saturated fat The aim of this study was to evaluate the effect of the Irvingia gabonensis kernel oil on plasma lipoproteins, blood glucose and liver lipids in rats. A feeding experiment was carried out in which rats were fed to a normal diet and the received a daily administration of oil 1 mL of Irvingia oil or desionised water water (controls). After 4 weeks, blood lipids, blood glucose liver and fecal lipids were mesured using standard methods. After 4 weeks the plasma HDL cholesterol (p<0.01) and triglyceride levels (0.01) were higher in Irvingia oil group. There was no difference in plasma cholesterol and LDL cholesterol level but LDL:HDL and total cholesterol:HDL ratios (p<0.01) were significantly lower after the administration of the Irvingia oil. The Blood glucose level (p<0.01) of animals receiving Irvingia oil was also lower compare to controls. The liver cholesterol (p<0.01) and triglyceride levels (P<0.002) were significantly higher in Irvingia oil group. Although the Irvingia oil has a myristic acid and lauric acid values of 39.2 and 51.1%, respectively, the hypocholesterolemic effect can be explain by high the Vitamin A, $- carotene and may be phytosterols levels.