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Insulin Resistance in the Fat Cells

Posted Mar 06 2010 2:14pm
The first step in Insulin Resistance is fatty deposits in the liver. At this stage, it's not too big of a problem, as there aren't that many symptoms. So we keep on eating the way we always have.

Next comes Insulin Resistance in the muscles. At this point, we begin to put on excess weight. We begin experiencing glycogen storage issues and symptoms, blood glucose problems, excess blood fats, and tiredness. We begin experiencing serious health issues from the Insulinemia.

Sometimes our ill health is enough to cause us to change our lifestyle. To go on a diet. To get up off of the sofa and exercise. But sometimes, it's not.

Sometimes we rationalize all of our health problems away in an attempt to justify our current, unhealthy lifestyle. We blame the excess weight on age. We blame our inability to stay on a diet on our food addictions and social behavoirs. We say we don't care that we've put on a few extra pounds. That it's normal in our current society. We don't want to look like Twiggy anyway.


If we keep on eating the way we always have, if we keep on embracing our sedentary ways, all of those excess calories have got to go someplace. And while we may, or may not be overeating in regards to volume of food, the liver and muscle glycogen dysfunction is serious enough to either make us obese, with all of those extra health issues, or turn us into what is known as Metabolic Syndrome.

Now we come to the end of the road, where even the fat cells begin to rebel. Because their job isn't to continuously fill themselves up with fats. Their function is to switch between fatty acid uptake, and release. Their function is to buffer the flux of fatty acids in the circulation in the face of dietary input of fatty acids. The role of the fat cells is to absorb fatty acids when there are too many around, then release them when they are scarse.

But if they're never scarse, if the buffering capacity gets overwhelmed by consistant intake of dietary fats over and above the rate of oxidation, all of those fats have got to go somewhere. And that somewhere is the liver, muscles, pancreas, and adipose tissues; thus eventually causing full body Insulin Resistance.

As fat cells fill up with Triglyceride, they become resistant to Insulin, causing even more Triglyceride to build up in the bloodstream and body organs. Hence the Metabolic Syndrome. Not a good thing as far as heart disease, stroke, and other fat-related diseases are concerned.

This is the point where quite a few folks decide that they want to enter into the Low Carb Lifestyle. And as far as low carbing goes, total body Insulin Resistance is a good position to be in. Especially if you have only a moderate amount of weight to lose. Because at this point in the progression, the body is no longer in fat storage mode. So when you eliminate most of the carbs from your diet, irregardless of the level of insulin, the fat just falls off of you.

Atkins' Magic. Metabolic Advantage. Whatever you want to call it, the results seem to defy the laws of Thermodynamics. And if it's your first time of attempting a low carb diet, you can get very good results with any of the low-carb programs, provided you stick with it, change your lifestyle, and make it all the way to goal weight. Then follow the Maintenance Program for life.

Not everyone chooses to do that though. Some of us didn't understand the consequences for not turning low-carb into a lifestyle the first time that we tried it. Some of us left the movement for various reasons, good or bad, only to find that upon our return, our bodies didn't work quite the same way as they did before. Some still found magic, just a little bit slower. And some of us found absolutely no metabolic advantage at all.

So I want to apologize a bit here for being so cynical in regards to low carbing lately. I just really want to figure all of this out, what is actually happening to me, so that I can make the adjustments I need to make in order to finally reach a healthy weight.

All of the research I've done on Insulin Resistance lately points to the fact that the problem I'm having with a low-carb, high-fat diet not working for me, might not be because low-carb itself doesn't work. Maybe it has something to do with the fact that low-carb the first or second time around healed the adipose tissue insulin resistance, which then made it harder to lose the weight from thereon in. Low carb, or not.


Maybe the reason why I've had to lower my fat and calorie intake almost from the very start of my journey this time around, is because I'm battling liver and muscle insulin resistance, rather than total body insulin resistance. And as a result, dietary fat and overall calories matter more than they otherwise would.

I don't know. What do YOU think....
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