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Body mass index and coronary heart disease

Posted Nov 19 2009 10:02pm
C G Owen et al ( 2009 ) Is body mass index before middle age related to coronary heart disease risk in later life? Evidence from observational International Journal of Obesity (2009) 33, 866–877;

Although obesity beginning early in life is becoming more common, This study examined the relationship of body mass index (BMI) before 30 years of age to CHD risk in later life.
A systematic review of published studies relating BMI between age 2 and 30 years to later CHD risk using papers reported over 40 + years..

A total of 15 studies provided 17 estimates (731 337 participants, 23 894 CHD events) of the association of early BMI to later CHD outcome. BMI in early childhood (2–6 years, 3 estimates) showed a weak inverse association with CHD risk (RR 0.94, 95% CI 0.82–1.07). BMI in later childhood (7 to <18 years, 7 estimates) and BMI in early adult life (18–30 years, 7 estimates) were both positively related to later CHD risk (RR 1.09, 95% CI 1.00–1.20; RR 1.19, 95% CI 1.11–1.29 respectively). However, there was considerable statistical heterogeneity between study estimates. Results were unaffected by adjustment for social class and/or cigarette smoking, blood pressure and/or total cholesterol, in studies with available data. Gender and year of birth (1900–1976) had little effect on the association.

BMI is positively related to CHD risk from childhood onwards; the associations in young adults are consistent with those observed in middle age. Long-term control of BMI from childhood may be important to reduce the risk of CHD.
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