|Valid for practice|
|True to literature|
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In the rare situation where fibrinolytics may be indicated in cardiac arrest from PE or Acute Myocardial Infarction (AMI), what's the dose?
Take Home Points
- The dose of tPA in cardiac arrest is somewhere between 50-100 mg given as a bolus +/- infusion.
- According to the 2010 AHA Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care , "Ongoing CPR is not an absolute contraindication for fibrinolysis."
- Some studies suggest allowing 15 minutes of CPR for drug to work.
- Evidence is 'best' for PE; data does not support for undifferentiated cardiac arrest.
- Anticoagulants, such as heparin, were used in most studies along with the fibrinolytic.
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