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How many times have you given your patient IM ceftriaxone for that presumed gonococcal infection? ... still counting?
Many of us learned (or at least thought we learned) that ceftriaxone has to be administered IM to get the ‘depot’ effect.
Myth busted: There is no depot effect. IV and IM ceftriaxone have very similar pharmacokinetic profiles. Let me prove it to you, straight from the FDA-approved ceftriaxone package insert.
Time after dose administration (hrs) and Average plasma concentration (mcg/mL)