|Valid for practice|
|True to literature|
"Give em' a dose of vanc before they go," right?
Here is why giving one dose of IV vancomycin for SSTIs in stable patients is a bad idea:
Some will argue that we should still give SSTI patients one dose of IV antibiotics and send them out on the same PO antibiotics - i.e. clindamycin. Remember that infusion time for IV antibiotics is usually 30-60 minutes, the same time it takes for the antibiotics to be absorbed from the GI tract, so giving 1 dose of IV antibiotics as a "load" before discharge is not necessary.
Oral antibiotics commonly used for SSTIs and their bioavailability (source - package inserts):
Reference Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary. Clin. Infect. Dis. 2011;52(3):285–92. Pubmed 21217178
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