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Broad Institute of MIT and Harvard Uses Helicos Sequencing Technology – Single molecule processing

Posted May 09 2009 10:41pm

Helicos single-molecule sequencing technology generates large numbers of reads and does not require amplification of the DNA during the sample image preparation.  Helicos uses single molecule sequencing, which a while back, I had the opportunity to learn more about sequencing from an interview I did with Dr. Patrice Milos.  Stanford University also uses Helicos sequencing machines and products.  

Helicos BioSciences and Personalized Medicine - Featured Interview with Dr. Patrice Milos

The Broad Institute of MIT and Harvard   reports that the Helicos Technology is a good fit for their research and development. 

Single Cell Gene Sequencing from Helicos – How it works

The video below also shows how single cell sequencing has a time advantage and a bit about how it all works.  BD 

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The Helicos System Produces Better Scientific Results with Less Sequencing Required

CAMBRIDGE, Mass.--( BUSINESS WIRE )--Helicos BioSciences (Nasdaq:HLCS) was featured prominently at The Biology of Genomes meeting this week at Cold Spring Harbor Laboratory. At the meeting, Helicos scientists and their collaborators presented scientific results using the Helicos Genetic Analysis system describing novel views of genome structure and function, and the high productivity gains available from single molecule sequencing versus the competing next-gen platforms.

Three sets of Helicos data were presented at the annual Biology of Genomes meeting, a cornerstone scientific conference for the genome community.

Overall, he said the Helicos sequencer is currently well-suited for "counting applications" such as transcriptome analysis, copy number variation analysis, and ChIP-seq because it generates "cheap abundant reads," has a "very easy" sample prep that involves no amplification, and requires small amounts of starting material.

http://www.genomeweb.com/sequencing/broad-institute-uses-helicos-sequencing-tech

Related Reading:

An Introduction to Genomics – Humans have Bugs just like Windows does and It’s all about the Code

Helicos BioSciences and Personalized Medicine - Featured Interview with Dr. Patrice Milos

Personalized medicine will rely on IT – It’s all about Software
Helicos Ships Sequencer to Stanford University

Helicos Launches Open Access Web Site With Microbial Genome Data

Single Cell Gene Sequencing from Helicos – How it works
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