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Women with High FSH And High AMH Are Twice as Likely To Have Success With IVF

Posted Aug 05 2013 12:00am

High AMH and High FSH fertility
Over the past couple of months I’ve been listening into Fertility Insights, a live webcast series run by Center for Human Reproduction, a fertility clinic in New York.

It’s a program where fertility doctors and researchers from the Center for Human Reproduction (or CHR) discuss fertility research that affects and interests everyday men and women who struggle with infertility.  The webcast is a breath of fresh air because it covers scientific studies by relating them to issues that real couples and individuals with infertility face.

Their first episode concentrated on discussing recent research that examined the relationship between two blood tests that every women who’s been through infertility treatment is probably familiar with:
  • FSH (follicle-stimulating hormone)
  • AMH (anti- Müllerian hormone)
Sufferers of diminished ovarian reserve (or DOA) probably know the high FSH/low AMH combination, which indicates that ovarian function isn’t in optimal health. DOA means that pregnancy chances without fertility treatment are low.

Though this high FSH/low AMH combination is one of the most common presentations amongst women with DOA, AMH and FSH levels can be abnormal in other patterns – such as high FSH and high AMH. This combination is somewhat unusual, and the researchers from CHR took a look at what it means to have hormone levels like this.

CHR’s researchers found that during IVF, these women had 4 times as many eggs retrieved and were nearly twice as likely to get pregnant after IVF.  This is compared to women with other FSH/AMH combinations. 

Although they recognized that this group of women represents a very small percentage of women with infertility, it’s still great news! Specialists are closer to understanding why having a high FSH may not be terrible news for your fertility, if coupled with other factors, such as (in this particular study) a high AMH. 

The study’s results also highlights the importance of not just looking at FSH levels when assessing a woman’s ovarian reserve – your specialist should also measure other hormonal blood tests, such as AMH, and interpret the different levels in relation to each other.

You can find the full study details and results in the Journal of the Endocrine Society . But if I were you and wanted to learn more, I’d just check out the webcast. It’s easier to digest for the non-medically trained and it’s followed by some pretty interesting Q&A session between Dr. Norbert Gleicher, the study’s head researcher, and some actual patients.

Here’s a recording of the webcast. The audio has an echo for the first 4 minutes, but after that it clears up. 

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