Vortex Counter-Current Chromatography (CCC) System
Posted Aug 31 2010 5:00pm
Description of Invention: Available for licensing and commercial development is a vortex counter-current chromatography system. The system has a rotary frame engaged to a vortex separation column for rotation in one direction through a vortex separation shaft engaged to a pulley system. The rotary frame is engaged to a central shaft that rotates the rotary frame in a direction opposite that of the vortex separation column such that planetary motion is imparted to the vortex separation column. The vortex separation column may be configured to receive a solvent system separable between two immiscible liquid phases introduced into the vortex separation column. A pulley system is operatively engaged to the separation column shaft and the central shaft for rotating the separation column shaft and the cortex separation column in a synchronous rotational direction opposite to the rotational direction of the rotary frame for imparting a type-I planetary motion to the vortex separation column. A counter-weight column is engaged at a symmetrical position opposite the vortex separation column along the rotary frame, wherein the two immiscible liquid phases undergo a vortex motion during rotation of the vortex separation column such that mixing of the two immiscible liquid phases takes place with a plane perpendicular to an axis of the vortex separation column.
Compared with conventional CCC systems, the vortex system has much higher partition efficiency in terms of height equivalent to a theoretical plate (only 2 cm compared with 20 cm that is required for the conventional system). The vortex system also provides an advantage of low column pressure which facilitates application of a large industrial-scale separation without a risk of leakage of solvent and column damage caused by high pressure.
Ito Y, Bowman RL. Countercurrent chromatography with flow-through coil planet centrifuge. Science 1971;173:420-422. [ PubMed: 5557320 ]
Ito Y, Bowman RL. Countercurrent chromatography with flow-through coil planet centrifuge. J Chromatogr Sci. 1973 Jun;11(6):284-291.
Licensing Status: Available for licensing.
Portfolios: Devices/Instrumentation Devices/Instrumentation - Research Tools and Materials
For Licensing Information Please Contact: Michael Shmilovich Esq. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: shmilovm@mail.nih.gov Phone: 301-435-5019 Fax: 301-402-0220
Description of Invention:
Available for licensing and commercial development is a vortex counter-current chromatography system. The system has a rotary frame engaged to a vortex separation column for rotation in one direction through a vortex separation shaft engaged to a pulley system. The rotary frame is engaged to a central shaft that rotates the rotary frame in a direction opposite that of the vortex separation column such that planetary motion is imparted to the vortex separation column. The vortex separation column may be configured to receive a solvent system separable between two immiscible liquid phases introduced into the vortex separation column. A pulley system is operatively engaged to the separation column shaft and the central shaft for rotating the separation column shaft and the cortex separation column in a synchronous rotational direction opposite to the rotational direction of the rotary frame for imparting a type-I planetary motion to the vortex separation column. A counter-weight column is engaged at a symmetrical position opposite the vortex separation column along the rotary frame, wherein the two immiscible liquid phases undergo a vortex motion during rotation of the vortex separation column such that mixing of the two immiscible liquid phases takes place with a plane perpendicular to an axis of the vortex separation column.
Compared with conventional CCC systems, the vortex system has much higher partition efficiency in terms of height equivalent to a theoretical plate (only 2 cm compared with 20 cm that is required for the conventional system). The vortex system also provides an advantage of low column pressure which facilitates application of a large industrial-scale separation without a risk of leakage of solvent and column damage caused by high pressure.
Applications:
Inventors:
Yoichiro Ito (NHLBI)
Patent Status:
HHS, Reference No. E-196-2010/0
US, Application No. 61/368,157 filed 27 Jul 2010
Relevant Publication:
Licensing Status:
Available for licensing.
Portfolios:
Devices/Instrumentation
Devices/Instrumentation - Research Tools and Materials
For Licensing Information Please Contact:
Michael Shmilovich Esq.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: shmilovm@mail.nih.gov
Phone: 301-435-5019
Fax: 301-402-0220
Ref No: 2156
Updated: 09/2010