Description of Invention:
NIH researchers have produced transgenic mice over expressing human tissue inhibitor of metalloproteinases-1 (hTIMP) in the liver under the control of an albumin promoter. These mice produce large amounts of hTIMP-1 for extended periods of time, resulting in high levels of biologically active inhibitor released into the systemic circulation. In considering that the sustained high levels of circulating hTIMP-1 do not appear to affect the general health of these mice, this model can be used to study the protective effects of TIMP-1 on diseases, which involve extensive proteolytic matrix degradation and tissue remodeling. Examples of such diseases include malignant tumors, liver fibrosis, wound healing, rheumatoid arthritis, and a variety of angioproliferative diseases.

Inventors:
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Portfolios:
Devices/Instrumentation
Devices/Instrumentation - Research Tools and Materials
Animal Model



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Ref No: 1132

Updated: 06/2010