Spectrum of Diseases/Conditions

  Contents:

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  Addiction  

• Maintenance of abstinence from alcohol in patients with alcohol dependency
• NAS (neonatal abstinence syndrome)
• Smoking cessation

  Analgesia/Anesthesiology/Anti-inflammatory        

• Anesthesia
• Anxiolysis
• Familial Mediterranean Fever (FMF)
• Fever reduction
• Juvenile Idiopathic Arthritis (JIA)/Juvenile Rheumatoid Arthritis (JRA)
• Management of fibromyalgia
• Pain
  • Chronic
  • Malignancy-related breakthrough pain
  • Mild
  • Moderate
  • Post-operative
  • Severe
• Sedation
  • Initially intubated & mechanically ventilated pediatric subjects in an intensive care setting
• Skeletal muscle relaxation to facilitate rapid sequence and routine endotracheal intubation

  Cardiovascular Disease      

• Congestive heart failure
• Hypertension
  • General
  • Post-operative hypertension
• Pulmonary hypertension
  • Primary/secondary
  • Post-surgical
• Raynaud's Phenomenon
• Tachyarrhythmia

  Dermatology        

• Alopecia areata
• Aphthous ulcer
• Candidiasis (cutaneous)
• Dermatosis (steroid-responsive dermatosis)
• Dermatitis (atopic dermatitis)
• Ichthyosis vulgaris
• Molluscum contagiosum
• Oral mucositis
• Pediculosis humanis capitis (head lice and their ova)
• Severe recalcitrant nodular acne
• Skin and skin structure infections
• Tinea
  • Capitis
  • Cruris
  • Pedis

  Endocrinology/Metabolism        

• Acromegalic gigantism
• Bone mineral density (BMD)
  • BMD in anorexia nervosa patients
  • BMD in osteogenesis imperfecta patients
  • BMD in postmenarcheal adolescents with secondary amenorrhea
• Delayed puberty in boys with primary and secondary hypogonadism
• Diabetes Mellitus
  • Type 1
  • Type 2
• End stage renal disease
• Failure to thrive in pediatric AIDS patients
• Growth-hormone-secreting lesions of the pituitary gland
• Gynecomastia
• Hypercholesterolemia (heterozygous familial hypercholesterolemia)
• Hyperparathyroidism (renal failure secondary to hyperparathyroidism)
• Hypocalcemia management in patients on hemodialysis
• McCune-Albright Syndrome
• Obesity
  • General
  • Hypothalamic
• Osteogenesis Imperfecta (OI)
• Tetrahydrobiopterin- (BH4-) responsive phenylketonuria (PKU)
• Testotoxicosis

  Gastroenterology        

• Antiemesis
  • Treatment and prevention of nausea and vomiting associated with emetogenic chemotherapy
  • Prevention of post-operative nausea and vomiting
• Constipation (general )
• Crohn's Disease
• Diarrhea (acute)
• Erosive Esophagitis 
• Gastroesophageal Reflux Disease (GERD)
• Irritable Bowel Syndrome (IBS)
• Ulcerative Colitis (UC)
• Ulcers

  Hematology/Coagulation        

• Deep vein thrombosis (DVT)
• Iron deficiency in patients undergoing chronic hemodialysis
• Thrombocythemia
• Thrombocytopenia
• Thromboembolism

  Immunomodulators        

• Immune suppression
• Prevention of organ rejection following renal transplantation

  Infectious Disease (viral)        

• Acute pyelonephritis
• Complicated UTI
• Cytomegalovirus (CMV)
• Hepatitis B virus (HBV)
• Hepatitis C virus (HCV)
• Herpes simplex virus (HSV)
• Human immunodeficiency virus (HIV) infection and/or prophylaxis of HIV infection in exposed neonates
• Influenza A/B
• Perinatal transmission of HIV infection
• Varicella zoster virus (VZV)

  Infectious Disease (non viral)        

• Aspergillosis (invasive)
• Candidiasis
Complicated intra-abdominal infections (cIAI)
• Community-acquired pneumonia (CAP)
• Cerebrospinal fluid (CSF) shunt infection
• Fungal infection (invasive)
  • Associated fever and neutropenia
• Helicobacter pylori infection (H. pylori)
• Malaria
• Meningitis (bacterial)
• Mold infections (rare mold)
• Otitis media (OM)(recurrent)/OM treatment failures
• Pneumonia (bacteremic)
• Resistant infection or infections unresponsive to the first choice antibiotic
• Skin and skin structure infections
• Symptoms associated with common cold and influenza
• Tuberculosis

  Medical Imaging        

• Myocardial perfusion imaging
• Lesions in the central nervous system, body, extracranial/extraspinal tissues
• Cardiac imaging

Neurology        

• Adolescent schizophrenia
• Anti-convulsant
• Attention deficit hyperactivity disorder (ADHD)
  • ADHD in patients with Tourette's disorder
• Bipolar disorder (mania associated with bipolar disorder)
• Depression/Major Depressive Disorder (MDD)
• General Anxiety Disorder (GAD)
• Insomnia in patients with ADHD
• Migraine
• Multiple sclerosis (MS)
• Narcolepsy
• Obstructive sleep apnea (OSA) (excessive sleepiness in OSA)
• Obsessive compulsive disorder (OCD)
• Panic disorder
• Seizures
  • Generalized
  • Partial
• Spasticity management
• Tourette’s syndrome

  Oncology        

• Allogeneic bone marrow transplants
• Antiemesis
  • Treatment and prevention of nausea and vomiting associated with emetogenic chemotherapy
  • Prevention of post-operative nausea and vomiting
• Antineoplasia
• Brain tumors and other solid tumors
• Chemotherapy toxicity protection
• CNS malignancies and solid tumors
• Hematologic tumors
  • CNS lymphomas
  • Leukemia
    • Acute lymphoblastic leukemia
    • Acute myelogenous leukemia
    • CNS leukemia
    • Mixed linear acute leukemia
    • Philadelphia positive (Ph+) chronic myelogenous leukemia
  • Hodgkin's lymphoma
  • Non-Hodgkin's lymphoma
• Hematopoietic stem cell mobilization in patients with pediatric malignancies eligible for autologous stem cell transplantation
• Neuroblastoma
• Pediatric malignancies
• Refractory/relapse malignancies
• Sickle cell disease

  Ophthalmology        

• Conjunctivitis
  • Allergic
  • Bacterial
  • Neonatal
• Intraocular pressure
• Post-operative inflammation following cataract surgery
• Uveitis

  Other Therapeutic Areas        

• Detrusor Hyperreflexia
• Detrusor overactivity in neurological condition
• Symptoms associated with common cold and influenza

  Pulmonary        

• Allergic Rhinitis
• Asthma
• Bronchopulmonary dysplasia
• Bronchospasm (treatment and prevention)
  • Prevention of bronchospasm in patients with obstructive airway disease
• Idiopathic urticaria (chronic)