Software System for Quantitative Assessment of Vasculature in Three Dimensional Images
Posted Nov 30 2010 7:00pm
Description of Invention: This invention offered for licensing and further development is a software system that provides the capability of efficiently extracting, visualizing and quantifying three dimensional vascular networks from medical and basic research images. Deregulation of angiogenesis plays a major role in a number of human diseases, most notably cancer. A substantial increase in the research effort in this field over the past decade has deepened the understanding of the angiogenic process. However, the lack of methods and software to quantitatively assess vasculature in patients has considerably hampered the ability to directly study the angiogenesis process, as well as to discover and develop new therapeutics to modulate angiogenesis. The present invention provides new semi-automated computer algorithms, statistical methods and user friendly visualization tools for rapid and intuitive quantitative evaluation of vasculature in three dimensional data sets obtained through non-invasive imaging techniques such as MRI, CT-Scans, confocal microscopy, microCT, etc. The methods and software embodied in this invention provide a three dimensional quantitative capability in the clinic as a vascular diagnostic tool and in basic research projects to evaluate changes in vascular network systems.
Applications:
Medical research for studying angiogenesis and tumor vasculature
Potential applications in clinical studies and diagnostics
Discovery and development of anti-angiogenesis agents with application to cancer
Possible application to diseases other than cancer, such as those related to the lymphatic system, the pulmonary airway, the kidney filtration system
Development Status:
The invention is fully developed.
The software will be readily available if so requested.
Inventors: Christopher Kurcz (NCI) Enrique Zudaire Ubani (NCI) Yanling Liu (NCI)
Patent Status: HHS, Reference No. E-261-2010/0
Software – Patent protection is not being pursued for this technology.
For Licensing Information Please Contact: Michael Shmilovich Esq. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: shmilovm@mail.nih.gov Phone: 301-435-5019 Fax: 301-402-0220
Description of Invention:
This invention offered for licensing and further development is a software system that provides the capability of efficiently extracting, visualizing and quantifying three dimensional vascular networks from medical and basic research images. Deregulation of angiogenesis plays a major role in a number of human diseases, most notably cancer. A substantial increase in the research effort in this field over the past decade has deepened the understanding of the angiogenic process. However, the lack of methods and software to quantitatively assess vasculature in patients has considerably hampered the ability to directly study the angiogenesis process, as well as to discover and develop new therapeutics to modulate angiogenesis. The present invention provides new semi-automated computer algorithms, statistical methods and user friendly visualization tools for rapid and intuitive quantitative evaluation of vasculature in three dimensional data sets obtained through non-invasive imaging techniques such as MRI, CT-Scans, confocal microscopy, microCT, etc. The methods and software embodied in this invention provide a three dimensional quantitative capability in the clinic as a vascular diagnostic tool and in basic research projects to evaluate changes in vascular network systems.
Applications:
Development Status:
Inventors:
Christopher Kurcz (NCI)
Enrique Zudaire Ubani (NCI)
Yanling Liu (NCI)
Patent Status:
HHS, Reference No. E-261-2010/0
Software – Patent protection is not being pursued for this technology.
Licensing Status:
Available for licensing.
Portfolios:
Devices/Instrumentation
Devices/Instrumentation - Software
For Licensing Information Please Contact:
Michael Shmilovich Esq.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: shmilovm@mail.nih.gov
Phone: 301-435-5019
Fax: 301-402-0220
Ref No: 2200
Updated: 12/2010