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Semi-Automated Cell Bioassay for Detection of Saxitoxins, Brevetoxins, and Ciguatoxins

Posted Jan 15 2013 7:00pm

Description of Invention:
This invention details a rapid and simplified tissue culture test method for the detection of hazardous marine toxins, such as saxitoxins, brevetoxins, and ciguatoxins, occasionally present in consumable finfish and shellfish. The present invention, which will be very useful in the seafood industry, is a cell bioassay wherein a colorimetric method, which requires only minimal processing, provides results that can be read either visually or on a standard multiwell scanning spectrophotometer. This technology is parallel to and a replacement for the mouse bioassay currently used in the detection of neurotoxins with significantly improved sensitivity in the order of 10,000 times. In addition, this bioassay can be effected within four to six hours of exposure to the toxin, as compared to the 24-48 hour response period required in the mouse bioassay.

Ronald L Manger (FDA)
Linda S Leja (FDA)
Sue Y Lee (FDA)
James M Hungerford (FDA)
Marleen M Wekell (FDA)

Patent Status:
HHS, Reference No. E-127-1993/0
US, , Patent No. 5,420,011, Issued 30 May 1995
US, , Patent No. 6,174,690, Issued 16 Jan 2001

Related Technologies:
US, Patent No. 5,858,687, Issued 12 Jan 1999, Reference No. E-127-1993/1

For Licensing Information Please Contact:
Charlene Sydnor Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-4689
Fax: 301-402-0220

Ref No: 125

Updated: 01/2013

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