Polymeric Silicone Hydrogel Vessel Mimetics for Cell Culturing
Posted Jul 15 2013 8:00pm
Description of Invention: The invention pertains to high oxygen diffusivity silicone hydrogel support structures that mimic tissue vasculature (e.g., capillary bed). Photolithographic methods are used to construct mimetic silicone hydrogel pillars that have, for example, a 20:1 height to diameter ratio. Advantageously, these mimetic silicone hydrogels diffuse oxygen from the bottom chamber to the cells cultured on the surface at near physiological rates (60 times that of water). Uses of these mimetics include 2-D screening for chemotherapeutic compounds and growth of tissue for grafting.
Simulation of physiological growth conditions
High oxygen diffusivity
In vitro data available
Inventors: Chandan K Das (NCI) Ashley A Jaeger (CIT) Thomas J Pohida (CIT) Randall Pursley (CIT) Philip G Mcqueen (CIT) Nicole Y Morgan (NIBIB) Michael M Gottesman (NCI)
For Licensing Information Please Contact: Michael Shmilovich Esq. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: firstname.lastname@example.org Phone: 301-435-5019 Fax: 301-402-0220