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Polymeric Silicone Hydrogel Vessel Mimetics for Cell Culturing

Posted Jul 15 2013 8:00pm

Description of Invention:
The invention pertains to high oxygen diffusivity silicone hydrogel support structures that mimic tissue vasculature (e.g., capillary bed). Photolithographic methods are used to construct mimetic silicone hydrogel pillars that have, for example, a 20:1 height to diameter ratio. Advantageously, these mimetic silicone hydrogels diffuse oxygen from the bottom chamber to the cells cultured on the surface at near physiological rates (60 times that of water). Uses of these mimetics include 2-D screening for chemotherapeutic compounds and growth of tissue for grafting.

  • Tissue engineering
  • Simulation of physiological growth conditions

  • High oxygen diffusivity

Development Status:
  • Prototype
  • Pilot
  • In vitro data available

Chandan K Das (NCI)
Ashley A Jaeger (CIT)
Thomas J Pohida (CIT)
Randall Pursley (CIT)
Philip G Mcqueen (CIT)
Nicole Y Morgan (NIBIB)
Michael M Gottesman (NCI)

Patent Status:
HHS, Reference No. E-070-2013/0
US, Application No. 61/758,198 filed 29 Jan 2013
US, Application No. 61/773,064 filed 05 Mar 2013

For Licensing Information Please Contact:
Michael Shmilovich Esq.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-5019
Fax: 301-402-0220

Ref No: 2591

Updated: 07/2013

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