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Polyclonal Antibodies for the Specialized Signaling G protein, Gbeta5

Posted Jul 26 2012 8:00pm

Description of Invention:
Researchers at NIDDK have developed polyclonal antibodies against the G protein, Gbeta5. Gbeta5 is a unique and highly specialized G protein that exhibits much less homology than other Gbeta isoforms (~50%) and is preferentially expressed in brain and neuroendocrine tissue. It is expressed prominently in the neuronal cell membrane, as well as in the cytosol and nucleus. Although this distribution pattern suggests that Gbeta5 may shuttle information between classical G protein-signaling elements at the plasma membrane and the cell interior, its function in the brain is largely unknown.

The antibodies were separately generated in rabbits to KLH-conjugates of peptides from the N-terminus of Gbeta5 (antibody ATDG) and the C-terminus of Gbeta5 (antibody SGS). The antibodies can be used for immunoblotting (ATDG, SGS), and immunoprecipitation (ATDG). They can be used to facilitate our understanding of the unique biology and function of Gbeta5 in brain and neurons.

Applications:
These antibodies can be used for research purposes (immunoblotting, immunoprecipitation) by those studying the biology and function of Gbeta5.

Advantages:
Very specific antibodies to study Gbeta5 and G protein signaling.

Development Status:
In vitro data available

Inventors:
William F Simonds (NIDDK)
Jianhua Zhang (NIDDK)


Patent Status:
HHS, Reference No. E-192-2006/0

Research Tool — Patent protection is not being pursued for this technology.

Relevant Publication:
  1. Zhang JH and Simonds WF. [ PMID 10648734 ]
  2. Zhang JH, et al. [ PMID 11152459 ]
  3. Zhang S, et al. [ PMID 8969224 ]
  4. Zachariou V, et al. [ PMID 16415864 ]



For Licensing Information Please Contact:
Jaime Greene M.S.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: greenejaime@mail.nih.gov
Phone: 301-435-5559
Fax: 301-402-0220


Ref No: 2467

Updated: 07/2012

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