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Novel Compositions for Use as Bone Scaffolds and Enhancers of Bone Regeneration

Posted Jun 15 2010 5:00pm

Description of Invention:
This invention is directed to the discovery that a mixture of an organic polymer and inorganic particles may hold therapeutic utility as a biomaterial for artificial bone scaffolds, injectable bone-filling materials, and enhancement of new bone generation. This composition has demonstrated utility in vivo in mice.

The inventors have discovered a means of producing a stably homogenous mixture of the organic polymer and inorganic particles by crosslinking the two components. In contrast to current technologies, this invention not only imparts sufficient mechanical and load-bearing strength but also provides a suitable environment for new bone formation. Importantly, since the chemical reaction applied to make this biomaterial does not produce any harmful molecules or heat, it can be used in an injectable form. Bone formation or replacement is often a desired therapy for bone loss or defects due to fractures or bone degenerative diseases.

Applications:
  • Injectable bone-filling materials
  • Artificial bone sponge for bone defect
  • Artificial bone sponge for bone cell culture in bone and mineralization research


Advantages:
  • Combines bone-like strength and a suitable environment for new bone formation
  • Injectable


Development Status:
  • Early stage
  • Tested in vivo in mice


Inventors:
EunAh Lee (NIDCR)
Pamela G Robey (NIDCR)


Patent Status:
HHS, Reference No. E-042-2007/0
US, Application No. 12/745,231 filed 27 May 2010


Relevant Publication:
  1. In preparation


Licensing Status:
Available for licensing.

Collaborative Research Opportunity:
The National Institute of Dental and Craniofacial Research, Craniofacial and Skeletal Diseases Branch, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology. Please contact David W. Bradley, Ph.D. at 301-402-0540 or bradleyda@nidcr.nih.gov for more information.


Portfolios:
Devices/Instrumentation
Devices/Instrumentation - Therapeutics
Internal Medicine
Internal Medicine - Therapeutics
In-vivo Data



For Additional Information Please Contact:
Charlene Sydnor Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: sydnorc@mail.nih.gov
Phone: 301-435-4689
Fax: 301-402-0220


Ref No: 2092

Updated: 06/2010

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