Novel Compositions for Use as Bone Scaffolds and Enhancers of Bone Regeneration
Posted Jun 15 2010 5:00pm
Description of Invention: This invention is directed to the discovery that a mixture of an organic polymer and inorganic particles may hold therapeutic utility as a biomaterial for artificial bone scaffolds, injectable bone-filling materials, and enhancement of new bone generation. This composition has demonstrated utility in vivo in mice.
The inventors have discovered a means of producing a stably homogenous mixture of the organic polymer and inorganic particles by crosslinking the two components. In contrast to current technologies, this invention not only imparts sufficient mechanical and load-bearing strength but also provides a suitable environment for new bone formation. Importantly, since the chemical reaction applied to make this biomaterial does not produce any harmful molecules or heat, it can be used in an injectable form. Bone formation or replacement is often a desired therapy for bone loss or defects due to fractures or bone degenerative diseases.
Injectable bone-filling materials
Artificial bone sponge for bone defect
Artificial bone sponge for bone cell culture in bone and mineralization research
Combines bone-like strength and a suitable environment for new bone formation
Tested in vivo in mice
Inventors: EunAh Lee (NIDCR) Pamela G Robey (NIDCR)
Collaborative Research Opportunity: The National Institute of Dental and Craniofacial Research, Craniofacial and Skeletal Diseases Branch, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology. Please contact David W. Bradley, Ph.D. at 301-402-0540 or firstname.lastname@example.org for more information.
Portfolios: Devices/Instrumentation Devices/Instrumentation - Therapeutics Internal Medicine Internal Medicine - Therapeutics In-vivo Data
For Additional Information Please Contact: Charlene Sydnor Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: email@example.com Phone: 301-435-4689 Fax: 301-402-0220