Neutralizing Monoclonal Antibody To Human Alpha PDGF Receptors
Posted Jun 09 2010 5:00pm
Description of Invention: These monoclonal antibodies specifically bind to an epitope on alpha PDGFR, inhibit PDGF binding with PDGF, antagonize PDGF, and does not bind beta PDGFR receptor. A hybridoma cell line producing such a monoclonal antibody, methods of in vivo imaging of a pathological condition, and methods of inhibiting the growth of a neoplasia expressing alpha PDGFR which use these monocloncal antibodies are also described. In vitro assays for detecting the presence of alpha PDGFR and for evaluating the binding affinity of a test compound are also described.
Inventors: William J Larochelle (NCI) Stuart A Aaronson (NCI)
Portfolios: Devices/Instrumentation Devices/Instrumentation - Diagnostics Cancer Cancer - Therapeutics Cancer - Research Materials Infectious Diseases Infectious Diseases - Research Materials Internal Medicine Internal Medicine - Other In-vitro Data
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