Health knowledge made personal
Join this community!
› Share page:
Search posts:

Neutralizing Monoclonal Antibody To Human Alpha PDGF Receptors

Posted Jun 09 2010 5:00pm

Description of Invention:
These monoclonal antibodies specifically bind to an epitope on alpha PDGFR, inhibit PDGF binding with PDGF, antagonize PDGF, and does not bind beta PDGFR receptor. A hybridoma cell line producing such a monoclonal antibody, methods of in vivo imaging of a pathological condition, and methods of inhibiting the growth of a neoplasia expressing alpha PDGFR which use these monocloncal antibodies are also described. In vitro assays for detecting the presence of alpha PDGFR and for evaluating the binding affinity of a test compound are also described.

William J Larochelle (NCI)
Stuart A Aaronson (NCI)

Patent Status:
HHS, Reference No. E-040-1993/0
US, , Patent No. 5,863,739, Issued 26 Jan 1999
US, , Patent No. 5,833,986, Issued 10 Nov 1998
HHS, Reference No. E-040-1993/0
PCT, Application No. PCT/US94/07006 filed 24 Jun 1994

Devices/Instrumentation - Diagnostics
Cancer - Therapeutics
Cancer - Research Materials
Infectious Diseases
Infectious Diseases - Research Materials
Internal Medicine
Internal Medicine - Other
In-vitro Data

For Additional Information Please Contact:
Susan Rucker J.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 30A,
Rockville, MD 20852
United States
Phone: 301-435-4478
Fax: 301-402-0220

Ref No: 139

Updated: 06/2010

Post a comment
Write a comment:

Related Searches