Neutralizing Monoclonal Antibody To Human Alpha PDGF Receptors

Description of Invention:
These monoclonal antibodies specifically bind to an epitope on alpha PDGFR, inhibit PDGF binding with PDGF, antagonize PDGF, and does not bind beta PDGFR receptor. A hybridoma cell line producing such a monoclonal antibody, methods of in vivo imaging of a pathological condition, and methods of inhibiting the growth of a neoplasia expressing alpha PDGFR which use these monocloncal antibodies are also described. In vitro assays for detecting the presence of alpha PDGFR and for evaluating the binding affinity of a test compound are also described.

Inventors:
William J Larochelle (NCI)
Stuart A Aaronson (NCI)


Patent Status:
HHS, Reference No. E-040-1993/0
US, , Patent No. 5,863,739, Issued 26 Jan 1999
US, , Patent No. 5,833,986, Issued 10 Nov 1998
HHS, Reference No. E-040-1993/0
PCT, Application No. PCT/US94/07006 filed 24 Jun 1994



Portfolios:
Devices/Instrumentation
Devices/Instrumentation - Diagnostics
Cancer
Cancer - Therapeutics
Cancer - Research Materials
Infectious Diseases
Infectious Diseases - Research Materials
Internal Medicine
Internal Medicine - Other
In-vitro Data



For Additional Information Please Contact:
Susan Rucker J.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 30A,
Rockville, MD 20852
United States
Email: ruckersu@mail.nih.gov
Phone: 301-435-4478
Fax: 301-402-0220


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Updated: 06/2010