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Nanoparticle Probes and Mid-Infrared Chemical Imaging for DNA Microarray Detection

Posted Jan 19 2011 7:00pm

Description of Invention:
The technology offered for licensing is a faster, more flexible, cost-effective microarray visualization. The invention describes and claims the mid-infrared chemical imaging (IRCI) to detect nanostructure-based DNA microarrays, which can be utilized in the life science research arena to examine gene expression and single nucleotide polymorphisms (SNPs), as well as to characterize entire genomes. The IRCI improves the signal-to-noise ratio (SNR) obtained for hybridized microarrayed spots compared to the commonly used fluorescence detection method. The improved method of this invention results in the sensitivity and precision for detecting pathogenic bacterial genes and can be utilized to detect low-expressing genes which cannot be identified by fluorescent-based DNA microarrays. Furthermore, the automated IRCI systems can also be fabricated for the dedicated detection of other (protein, tissue, biochemical, or chemical) microarrays.

DNA microarrays can be applied to the areas of environmental sciences, agriculture research, bio-defense, diagnostics, forensics, pharmacogenomics and toxicogenomics.

The invention provides a cost-effective, faster, more flexible, and less labor intensive microarray technology.

Development Status:
  • The invention is fully developed
  • Need to develop a commercialized kit and protocol

Magdi M Mossoba (FDA)

Patent Status:
HHS, Reference No. E-127-2010/0
US, Application No. 61/393,635 filed 15 Oct 2010

Licensing Status:
Available for licensing.

Devices/Instrumentation - Diagnostics
Devices/Instrumentation - Research Tools and Materials

For Licensing Information Please Contact:
Susan Ano Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-5515
Fax: 301-402-0220

Ref No: 2217

Updated: 01/2011

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