Nanoparticle Probes and Mid-Infrared Chemical Imaging for DNA Microarray Detection
Posted Jan 19 2011 7:00pm
Description of Invention: The technology offered for licensing is a faster, more flexible, cost-effective microarray visualization. The invention describes and claims the mid-infrared chemical imaging (IRCI) to detect nanostructure-based DNA microarrays, which can be utilized in the life science research arena to examine gene expression and single nucleotide polymorphisms (SNPs), as well as to characterize entire genomes. The IRCI improves the signal-to-noise ratio (SNR) obtained for hybridized microarrayed spots compared to the commonly used fluorescence detection method. The improved method of this invention results in the sensitivity and precision for detecting pathogenic bacterial genes and can be utilized to detect low-expressing genes which cannot be identified by fluorescent-based DNA microarrays. Furthermore, the automated IRCI systems can also be fabricated for the dedicated detection of other (protein, tissue, biochemical, or chemical) microarrays.
Applications: DNA microarrays can be applied to the areas of environmental sciences, agriculture research, bio-defense, diagnostics, forensics, pharmacogenomics and toxicogenomics.
Advantages: The invention provides a cost-effective, faster, more flexible, and less labor intensive microarray technology.
Portfolios: Devices/Instrumentation Devices/Instrumentation - Diagnostics Devices/Instrumentation - Research Tools and Materials Miscellaneous
For Licensing Information Please Contact: Susan Ano Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: email@example.com Phone: 301-435-5515 Fax: 301-402-0220