Description of Invention: The researchers produced heterozygous and homozygous mu opiate receptor knockout mice that displayed 54% and 0% of wild-type levels of mu opiate receptor expression, respectively. These knockout mice were generated by injecting 15-20 homologous, recombinant ES cells into blastocysts harvested from C57BL/6J mice and by implanting the blastocysts into the uteri of pseudopregnant CD-1 mice.
Morphine acts on opiate receptors found on spinal and supraspinal neurons in the central nervous system. There are three main subtypes of these receptors, mu, kappa, delta. Morphine produces an analgesic effect by acting through these receptors, especially the mu receptor. However, the roles played by each of these receptors in pain processing in either drug-free or morphine-treated states are not clear. A mu opiate receptor knockout mouse model can be used to elucidate mechanistic and behavioral roles of this receptor subtype.
Inventors: George R Uhl (NIDA)
Patent Status: HHS, Reference No. E-034-2003/0
I. Sora et al., “Opiate receptor knockout mice define mu receptor roles in endogenous mociceptive responses and morphine-induced analgesia,” Proc. Natl. Acad. Sci. USA 18 Feb 1997 94(4):1544-1549.
Licensing Status: In addition to licensing, the technology is available for further development through collaborative research opportunities with the inventors.
Portfolios: Devices/Instrumentation Devices/Instrumentation - Research Tools and Materials Animal Model
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