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Mice Lacking Expression of Chemokine Receptor CCR9 Generated by Gene Targeting (CCR9 KO Mice)

Posted Jun 15 2010 5:00pm

Description of Invention:
Chemokines and their receptors are key regulators of thymocytes migration and maturation in normal and inflammation conditions. The chemokine CCL25 is highly expressed in the thymus and small intestine. CCR9, the receptor for CCL25, is expressed on the majority of thymocytes, indicating that CCR9 and its ligand may play an important role in thymocyte development. To investigate the role of CCR9 during lymphocyte development, CCR9 knockout mice were developed. Knockout mice had increased numbers of peripheral gammadelta-T cells but reduced numbers of alphabeta-T cells. In competitive transplantation experiments bone marrow from CCR9 knockout mice was much less efficient at repopulating the thymus than control (wild type) bone marrow. Thus, CCR9 KO mice are a model for studying thymocyte development and trafficking in the body. Additionally, as the ligand for CCR9 is highly expressed in the small intestine, CCR9 potentially plays a role in the specialization of immune responses in the gastrointestinal tract.

Applications:
  • Evaluate drugs aimed at blocking or augmenting lymphocyte trafficking
  • A model for studying T cell development
  • A model for studying immunological based gastrointestinal disorders


Inventors:
Paul E Love (NICHD)
Joshua M Farber (NIAID)
Shoji Uehara (NICHD)


Patent Status:
HHS, Reference No. E-328-2006/0


Relevant Publication:
  1. S Uehara et al. A role for CCR9 in T lymphocyte development and migration. J Immunol. 2002 Mar 15;168(6):2812-2819. [ PubMed abs ]
  2. S Uehara et al. Characterization of CCR9 expression and CCL25/thymus-expressed chemokine responsiveness during T cell development: CD3highCD69+ thymocytes and gammadelta TCR+ thymocytes preferentially respond to CCL25. J Immunol. 2002 Jan 1;168(1):134-142. [ PubMed abs ]


Licensing Status:
This technology is available as a research tool under a Biological Materials License.


Portfolios:
Devices/Instrumentation
Devices/Instrumentation - Research Tools and Materials
Internal Medicine
Internal Medicine - Research Materials
Animal Model



For Additional Information Please Contact:
Jennifer Wong
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: wongje@mail.nih.gov
Phone: 301-435-4633
Fax: 301-402-0220


Ref No: 1465

Updated: 06/2010

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