Market Research Report||Cell-Based Assays for Drug Discovery
Posted Apr 12 2011 7:35am
The area of drug discovery tools is one of the newest and most important sectors of pharmaceutical research and development. The term drug discovery tools usually refers to high-content screening (HCS) and analysis and is composed of those applications that require sufficient levels of sample throughput, whereby complex cellular events and phenotypes can be studied. Elements of drug performance like toxicity and specificity can be established simultaneously using mixed cell types--primary cells, cell lines, cell subpopulations. HCS seeks to assess the impact of phenotypic and cellular changes that are brought about by gene modification (such as with RNA interference (RNAi) approaches) and/or drug (or compound) treatment. The purpose of this examination by TriMark Publications is to describe the specific segments of the global drug discovery tools market. Within this area, the report covers those segments that are highly active in terms of innovation and growth. Specifically, this study examines the markets for small lab equipment all the way up to highly automated, large automated platforms, as well as accessory equipment such as reagents, supplies and manufacturers’ original equipment manufacturer (OEM) additional equipment.
Table of Contents :
1. Overview 4 1.1 Objectives of the Report 4 1.2 Methodology 5 1.3 Scope of the Report 6 1.4 Executive Summary 7
2. Technologies and Product Offering for High-Content Analysis 10 2.1 Definition of High-Content Analysis and Why it is so Attractive a Discipline 11
3. Market Analysis of the High-Content Tools Space 31 3.1 High-Content Analysis Market Size and Growth 31 3.2 Market Survey to Assess Qualitative and Quantitative Parameters of the High-Content Analysis Space 31
4. Strategic Analysis of the High-Content Tools Space 58 4.1 High-Content Analysis Market Structure 58
5. High-Content Analysis Technology Platforms 65 5.1 Methods of Digital Imaging 65 5.2 Fluorescence Microscopy 65 5.3 Major High-Content Analysis Instrumentation 66
6. High-Content Analysis in Drug Selection, Screening and Biomarker Discovery 72 6.1 Stem Cells Used as a Drug Discovery Tool 73 6.2 Cellular Systems Biology for Development of Toxicity Panels in Drug Safety Testing 73
7. Company Profiles and Glossary of Terms in High-Content Analysis 80 7.1 Acumen Pharmaceuticals, Inc. 80
LIST OF FIGURES Figure 2.1: Scope of Biological Parameters Addressed via a Typical High-Content Analysis Experiment 13 Figure 2.2: Classes of Assays in Life Science Research and Drug Discovery Illustrating the Relationship between Cell-based Assays and High-Content Analysis 14 Figure 2.3: New Paradigm of Drug Discovery and Development Illustrating the Central and Essential Role of Screening 16
The area of drug discovery tools is one of the newest and most important sectors of pharmaceutical research and development. The term drug discovery tools usually refers to high-content screening (HCS) and analysis and is composed of those applications that require sufficient levels of sample throughput, whereby complex cellular events and phenotypes can be studied. Elements of drug performance like toxicity and specificity can be established simultaneously using mixed cell types--primary cells, cell lines, cell subpopulations. HCS seeks to assess the impact of phenotypic and cellular changes that are brought about by gene modification (such as with RNA interference (RNAi) approaches) and/or drug (or compound) treatment. The purpose of this examination by TriMark Publications is to describe the specific segments of the global drug discovery tools market. Within this area, the report covers those segments that are highly active in terms of innovation and growth. Specifically, this study examines the markets for small lab equipment all the way up to highly automated, large automated platforms, as well as accessory equipment such as reagents, supplies and manufacturers’ original equipment manufacturer (OEM) additional equipment.
Table of Contents :
1. Overview 4
1.1 Objectives of the Report 4
1.2 Methodology 5
1.3 Scope of the Report 6
1.4 Executive Summary 7
2. Technologies and Product Offering for High-Content Analysis 10
2.1 Definition of High-Content Analysis and Why it is so Attractive a Discipline 11
3. Market Analysis of the High-Content Tools Space 31
3.1 High-Content Analysis Market Size and Growth 31
3.2 Market Survey to Assess Qualitative and Quantitative Parameters of the High-Content Analysis Space 31
4. Strategic Analysis of the High-Content Tools Space 58
4.1 High-Content Analysis Market Structure 58
5. High-Content Analysis Technology Platforms 65
5.1 Methods of Digital Imaging 65
5.2 Fluorescence Microscopy 65
5.3 Major High-Content Analysis Instrumentation 66
6. High-Content Analysis in Drug Selection, Screening and Biomarker Discovery 72
6.1 Stem Cells Used as a Drug Discovery Tool 73
6.2 Cellular Systems Biology for Development of Toxicity Panels in Drug Safety Testing 73
7. Company Profiles and Glossary of Terms in High-Content Analysis 80
7.1 Acumen Pharmaceuticals, Inc. 80
LIST OF FIGURES
Figure 2.1: Scope of Biological Parameters Addressed via a Typical High-Content Analysis Experiment 13
Figure 2.2: Classes of Assays in Life Science Research and Drug Discovery Illustrating the Relationship between Cell-based Assays and High-Content Analysis 14
Figure 2.3: New Paradigm of Drug Discovery and Development Illustrating the Central and Essential Role of Screening 16
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