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Laser Scanning Microscopy for Three Dimensional Motion Tracking for Volumetric Data

Posted Apr 26 2010 5:00pm

Description of Invention:
The technology offered for licensing and for further development is in the field of volumetric tissue scanning microscopy. More specifically, the invention provides for a device, system and methods that can acquire and analyze volumetric data from a high-speed laser-scanning microscope and compute motion of the sample under the microscope in three dimensions. This computed motion is used to adjust position of the sample in real time to maintain field of view and relative location. This motion compensation scheme can be used to collect micron-scale information over time, which can be important in a number of research or medical device applications.

  • Biomedical research involving in vivo microscopy.
  • Real time tracking of cells or cellular structures.
  • Tracking tissue during various physiological perturbations and observation of dynamic physiological processes. Physiological perturbations include metabolic substrates, drug delivery and anoxia.
  • Potential applications in molecular diagnostic imaging.
  • Potential applications in medical procedures such as biopsy and microsurgery where information has to be collected from a specific microscope location over a period of time.

  • Improved analytical capabilities for biological processes.
  • Improved capabilities of accurately examining and studying physiological perturbations.
  • Potential improvement in medical procedures such as biopsy.
  • May readily be adaptable to commercial microscopes.

Development Status:
The invention is fully developed. Further work needs to be done in the following areas:
  • Adaptation to different types of microscopes
  • Further demonstration of utility of in-vivo imaging

James L Schroeder (NHLBI)

Patent Status:
HHS, Reference No. E-290-2009/0
US, Application No. 61/245,586 filed 24 Sep 2009

Relevant Publication:
  1. Schroeder JL, Luger-Hamer M, Pursley R, Pohida T, Chefd'Hotel C, Kellman P, Balaban RS. Short communication: Subcellular motion compensation for minimally invasive microscopy, in vivo: evidence for oxygen gradients in resting muscle. Circ Res. 2010 Apr 2;106(6):1129-1133. [ PubMed: 20167928 ]

Licensing Status:
Available for licensing.

Collaborative Research Opportunity:
The National Heart, Lung, and Blood Institute, Laboratory of Cardiac Energetics, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize automatic 3D volumetric motion tracking systems for use during in vivo microscopy. Please contact Denise Crooks, Ph.D. at 301-435-0103 or for more information.

Devices/Instrumentation - Diagnostics

For Additional Information Please Contact:
Michael Shmilovich Esq.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-5019
Fax: 301-402-0220

Ref No: 2108

Updated: 04/2010

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