Description of Invention: The invention pertains to devices for directly infusing cellular therapeutics into patient bone. The device monitors intra-bone pressure using pressure sensors disposed at its proximal end and adjusts infusion pressures during infusion such that intra-bone pressure does not exceed levels of systemic blood pressure. Such devices, apparatus and methods are particularly suitable for use in performing bone marrow transplants, particularly transplants that utilize cord blood as a stem cell source.
Applications: Drug delivery to bones
Therapeutic uptake efficiency
Drug delivery efficiency
In vitro data available
Inventors: Robert F Hoyt (NHLBI) Randall R Clevenger (NHLBI) Jeremy M Pantin (NHLBI) Timothy J Hunt (NHLBI) Omer Aras (CC) Richard W Childs (NHLBI)
Pantin JM, et al. "Optimization of an Intra-Bone Hematopoietic Stem Cell Delivery Technique in a Swine Model." Poster abstract presented at the 54th ASH Annual Meeting and Exposition, Atlanta, Georgia, December 8-11, 2012. [ Poster Abstract ]
Collaborative Research Opportunity: The National Heart, Lung, and Blood Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Intra-bone Drug Delivery Device and Method. For collaboration opportunities, please contact Denise Crooks at email@example.com .
For Licensing Information Please Contact: Michael Shmilovich Esq. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: firstname.lastname@example.org Phone: 301-435-5019 Fax: 301-402-0220