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Intra-bone Drug Delivery Device and Method

Posted Jun 17 2013 8:00pm

Description of Invention:
The invention pertains to devices for directly infusing cellular therapeutics into patient bone. The device monitors intra-bone pressure using pressure sensors disposed at its proximal end and adjusts infusion pressures during infusion such that intra-bone pressure does not exceed levels of systemic blood pressure. Such devices, apparatus and methods are particularly suitable for use in performing bone marrow transplants, particularly transplants that utilize cord blood as a stem cell source.

Applications:
Drug delivery to bones

Advantages:
  • Therapeutic uptake efficiency
  • Drug delivery efficiency
  • Target specificity


Development Status:
  • Prototype
  • In vitro data available


Inventors:
Robert F Hoyt (NHLBI)
Randall R Clevenger (NHLBI)
Jeremy M Pantin (NHLBI)
Timothy J Hunt (NHLBI)
Omer Aras (CC)
Richard W Childs (NHLBI)


Patent Status:
HHS, Reference No. E-165-2012/0
US, Application No. 61/771,463 filed 01 Mar 2013


Related Technologies:
US, Patent No. 8,409,166, Issued 02 Apr 2013, Reference No. E-196-1998/2


Relevant Publication:
  1. Pantin JM, et al. "Optimization of an Intra-Bone Hematopoietic Stem Cell Delivery Technique in a Swine Model." Poster abstract presented at the 54th ASH Annual Meeting and Exposition, Atlanta, Georgia, December 8-11, 2012. [ Poster Abstract ]


Collaborative Research Opportunity:
The National Heart, Lung, and Blood Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Intra-bone Drug Delivery Device and Method. For collaboration opportunities, please contact Denise Crooks at crooksd@nhlbi.nih.gov .


For Licensing Information Please Contact:
Michael Shmilovich Esq.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: shmilovm@mail.nih.gov
Phone: 301-435-5019
Fax: 301-402-0220


Ref No: 2577

Updated: 06/2013

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