Companies are required under 21 CFR 314.81(b)(3)(iii) to provide FDA with a six month advance notice of the discontinuation of sole source products that are life-supporting, life-sustaining or for use in the prevention of a debilitating disease or condition. From time to time, FDA also receives notification for other products. These discontinuations are provided below for informational purposes only.

To locate drugs that have already been discontinued, please consult the following:
Drugs@FDA
Orange Book Query
Orange Book Monthly Additions and Deletions

Drug Name	Company Information	Related Information
Agenerase (amprenavir) 150mg capsule updated 10/10/2007	GlaxoSmithKline 888-825-5249	Letter from GlaxoSmithKline (updated 10/10/2007)
5% Alcohol in 5% Dextrose Injection, USP, Glass Container 12/19/2007	Hospira, Inc. 877-946-7747	Hospira has made a business decision to discontinue manufacturing of 5% Alcohol in 5% Dextrose Injection drug product (NDC# 0409-1500-05)
Brevibloc Concentrate (esmolol HCl) 250 mg/mL, 10 mL ampul 8/24/2007	Baxter Healthcare Corporation	Baxter Healthcare Corporation has made a decision to discontinue Brevibloc Concentrate (esmolol HCl) 250 mg/mL, 10 mL ampul (NDC 10019-025-18 for the pack and NDC 10019-025-73 for the ampul). Letter from Baxter
Calciferol injection in oil (ergocalciferol) 3/19/2004	Schwarz Pharma 6140 W. Executive Drive Mequon, WI 53092 800-558-5114	Schwarz has discontinued manufacturing of calciferol
CEFOTAN (cefotetan injection) 6/9/2006	AstraZeneca Pharmaceuticals LP (AstraZeneca) - Contact Corporate Information Center at 800-236-9933.	The remaining inventory of CEFOTAN (cefotetan injection) has been depleted. AstraZeneca has no further plans to manufacture or distribute CEFOTAN (cefotetan injection). Other cefotetan injection products continue to be available.
Cortisporin Ophthalmic Suspension (neomycin and polymyxin B sulfates and hydrocortisone ophthalmic suspension) 6/5/2008	King Pharmaceuticals 800-776-3637	Letter from King Pharmaceuticals
Cortisporin Otic Suspension (neomycin and polymyxin B sulfates and hydrocortisone otic suspension, USP) 6/5/2008	King Pharmaceuticals 800-776-3637	Letter from King Pharmaceuticals
Cylert (pemoline) tablets and chewable tablets, all strengths 5/25/2005	Abbott Laboratories	Abbott has made the decision to discontinue Cylert tablets and chewable tablets Letter from Abbott
Cytoxan (cyclophosphamide) 25mg and 50mg tablets 9/24/2007	Bristol-Myers Squibb Company 609-897-2412	Bristol-Myers Squibb Company has made a decision to discontinue Cytoxan (cyclophosphamide) 25mg and 50mg tablets. Alternate products continue to be available from other companies.
Desyrel (trazodone) Tablets 50mg, 100mg, 150mg and 300mg tablets 9/21/2006	Bristol-Myers Squibb Company 609-897-2412	Alternate products continue to be available from other companies. Dear Healthcare Professional Letter
ELAVIL (amitriptyline hydrochloride) Tablets and Injection. 5/15/2003	AstraZeneca Pharmaceuticals LP (AstraZeneca) – Contact Corporate Information Center at: 800-236-9933	ELAVIL Injection is no longer available at AstraZeneca. The remaining inventory of ELAVIL Tablets will be depleted by December 31, 2003. AstraZeneca has no further plans to manufacture ELAVIL (amitriptyline hydrochloride) Tablets or Injection.
Ethmozine (moricizine hydrochloride) 200mg, 250g, and 300mg tablets 9/17/2007	Shire US Inc. 725 Chesterbrook Blvd. Wayne, Pa 19087 1-800-828-2088	Dear Healthcare Professional Letter
Exubera (insulin recombinant human, powder for inhalation) 10/19/2007	Pfizer 800-398-2372	Dear Healthcare Provider Letter
Faslodex * (fulvestrant) Injection, 2.5 ml (2 x 2.5 ml pre-filled syringe), (125 mg /2.5 ml (50 mg/ml) FASLODEX intramuscular injection), NDC 0310-0720-2510 11/2/2009	AstraZeneca Pharmaceuticals LP (AstraZeneca)-Contact the Corporate Communication Center at 1-800-236-9933	There is no remaining inventory within AstraZeneca's distribution network. The final expiration date of any Faslodex* (fulvestrant) Injection that may still be remaining in the market place is December 31, 2010. (The supply of the single 5.0 ml syringe [250 mg/5 ml (50 mg/ml)] Faslodex pack, NDC 0310-0720-50, is not affected, and is currently available.)
Florinef (fludrocortisone acetate tablets, USP) 6/8/2007	King Pharmaceuticals, Inc. 501 Fifth Street Bristol, Tennessee 37620 Professional Information Services Department: 800-776-3637	Dear Healthcare Provider Letter
Flovent Rotadisk (fluticasone propionate inhalation powder) 8/31/2004	GlaxoSmithKline 888-825-5249	Please see Dear Healthcare Professional letter for additional information.
Fortovase (saquinavir) capsules 200 mg 6/2/2005	Roche	Fortovase 200 mg capsules will be discontinued by February 15, 2006. Please see attached DHP letter for additional information. Dear Healthcare Professional Letter
Foscavir (foscarnet sodium) injection 10/31/2008	AstraZeneca Pharmaceuticals LP (AstraZeneca) Contact Corporate Information Center at 1-800-236-9933	The remaining inventory of Foscavir (foscarnet sodium) injection will be depleted by April 30, 2009. AstraZeneca has no further plans to manufacture or distribute Foscavir (foscarnet sodium) injection after April 30, 2009.
Geocillin (carbenicillin indanyl sodium) tablets 382 mg 4/8/2008	Pfizer	Pfizer has discontinued this product. There are no other FDA approved manufacturers currently for carbenicillin tablets.
Geref Diagnostic (sermorelin acetate for injection) 0.05mg base/amp 8/5/2008	EMD Serono 1-888-398-4567	EMD Serono has made a business decision to discontinue this product. Dear Healthcare Professional Letter
Humatin (Paromomycin Sulfate Capsules, USP) 2/7/2008	King Pharmaceuticals Professional Information Services Department 800-776-3637	King Pharmaceuticals has made a decision to discontinue Humatin (Paromomycin Sulfate Capsules, USP) Paromomycin continues to be available from another manufacture. Letter from King Pharmaceuticals
Humulin 50/50 Insulin updated 12/2/2009	Eli Lilly and Company 1-800-545-5979	Dear Healthcare Professional Letter (PDF - 201KB) Patient Information (PDF - 887KB)
Humulin U ULTRALENTE (HUMAN INSULIN [rDNA ORIGIN] EXTENDED ZINC SUSPENSION) 7/6/2005	Eli Lilly and Company	Dear Doctor Letter Patient Information
Humulin L LENTE (HUMAN INSULIN [rDNA ORIGIN] ZINC SUSPENSION) 7/6/2005	Eli Lilly and Company	Dear Doctor Letter Patient Information
HIVID (zalcitabine) tablets 7/26/2006	Roche Pharmaceuticals	The sale and distribution of its anti-HIV medication HIVID (zalcitabine) Tablets will be discontinued by December 31, 2006. Dear Health Care Professional Letter
Intal Inhaler (cromolyn sodium inhalation aerosol) 8/3/2009	King Pharmaceuticals	Dear Healthcare Professional Letter
Intal Nebulizer Solution (cromolyn sodium inhalation solution, USP) 6/2/2008	King Pharmaceuticals 800-776-3637	Letter from King Pharmaceuticals
Inversine (mecamylamine hydrochloride) Tablets, 2.5 mg 6/17/2009	Targacept, Inc. 336-480-2100	Dear Healthcare Professional Letter
Inulin in Sodium Chloride Injection, USP 9/26/2003	Questcor Pharmaceuticals, Inc.	Letter
Kefzol (cefazolin) all presentations 2/28/2003	Eli Lilly and Company	Letter
Kefurox (cefuroxime) all presentations 2/28/2003	Eli Lilly and Company	Letter
Kemadrin (procyclidine hydrochloride) 6/6/2008	King Pharmaceuticals 800-776-3637	Letter from King Pharmaceuticals
Lanoxin Elixir(digoxin) 6/3/2005	GlaxoSmithKline	This product has been discontinued by GSK. Roxane is producing digoxin elixir.
LEXXEL (enalapril maleate-felodipine ER) Tablets 12/19/2007	AstraZeneca LP (AstraZeneca) - Contact Corporate Information Center at 800-236-9933.	LEXXEL Tablets will be discontinued on July 31, 2008. AstraZeneca has no further plans to manufacture or distribute LEXXEL (enalapril maleate-felodipine ER) Tablets after July 31, 2008.
Lorabid (loracarbef, USP) capsules and suspension 10/27/2006	King Pharmaceuticals 888-840-5370	Letter from King Pharmaceuticals
Mandol (cefamandole) all presentations 2/28/2003	Eli Lilly and Company	Letter
Mitozytrex (Mitomycin for Injection) 9/12/2008	SuperGen (925) 560-0100	Other Mitomycin approved products continue to be available. This product was never commercialized.
Mivacron (mivacurium chloride) injection 6/23/2006	Abbott Laboratories	Alternative products that can be used in place of Mivacron continue to be available. Please call Abbott at 1-800-633-9110 for additional information.
Moban (molindone hydrochloride) 5 mg, 10 mg, 25 mg, and 50 mg Tablets 1/13/2010	Endo Pharmaceuticals Inc. 1-800-462-ENDO (1-800-462-3636)	Moban tablets have been discontinued and supplies are anticipated to be depleted by June 30, 2010.
Nandrolone Decanoate Injection 6/24/2009	Watson Pharmaceuticals (800) 272-5525	Watson Pharmaceuticals has discontinued this product because of the unavailability of the active pharmaceutical ingredient.
Neutrexin (trimetrexate glucuronate) Injection 6/14/2007	MedImmune, Inc.	Dear Healthcare Professional Letter
Nimotop (nimodipine) capsules 10/31/2008	Bayer HealthCare Pharmaceuticals 888-842-2937	Generic nimodipine remains available. Please see Dear Healthcare Professional Letter for additional information.
Nolvadex (tamoxifen citrate) 4/10/2006	AstraZeneca 800-236-9933	Letter
Novolin InnoLet disposable pens and Novolin PenFill 3 mL cartridges for Novolin R, N and 70/30 8/13/2009	Novo Nordisk 1-800-727-6500	Dear Healthcare Provider Letter Dear Patient Letter
Novolin L, Lente, human insulin zinc suspension [rDNA origin] 7/15/2003	Novo Nordisk Pharmaceuticals, Inc. Contact: 800-727-6500 Customer Service	Letter
NPH Iletin II (ISOPHANE INSULIN SUSPENSION, USP, PURIFIED PORK) 7/6/2005	Eli Lilly and Company	Dear Doctor Letter Patient Information Frequently Asked Questions
Original Prefilled Pen that Contains Humalog, Humalog Mix 75/25, and Humalog Mix 50/50 9/14/2010	Eli Lilly and Company	Dear Healthcare Professional Letter (PDF - 667KB) Important information on discontinuation of original Prefilled Pen containing Humalog (PDF - 744KB) Important information on discontinuation of original Prefilled Pen containing Humalog Mix 75/25 (PDF - 935KB) Important information on discontinuation of original Prefilled Pen containing Humalog Mix50/50 (PDF - 962KB)
ORLAAM (Levomethadyl hydrochloride acetate) Oral Solution, 10 mg/mL 9/2/2003	Roxane Laboratories	Letter
Pancrease (pancrelipase) capsules 5/17/2006	McNeil Consumer and Specialty Pharmaceuticals 888-440-7903	Other pancrelipase products continue to be available Dear Health Care Provider Letter
Perchloracap (potassium perchlorate) 200 mg capsules 6/2/2005	Tyco Healthcare	Perchloracap capsules have been discontinued and supplies are anticipated to be depleted by the end of 2005.
Procanbid (Procanamide Hydrochloride Extended-Release Tablets) 11/9/2007	King Pharmaceuticals 800-776-3637	Dear Prescriber Letter
ProSom (estazolam) Updated 5/2/2007	Abbott 200 Abbott Park Road Abbott Park, IL 60064-6157 Customer Service: 800-633-9110	Dear Health Care Provider Letter
Pulmicort Turbuhaler 200mcg (budesonide inhalation powder) 5/16/2007	AztraZeneca 1800 Concord Pike PO Box 8355 Wilmington DE 19803-8355 Corporate Information: 800-842-9920	NDA 20-441, PULMICORT TURBUHALER 200 mcg (budesonide inhalation powder) will no longer be available at AstraZeneca. The introduction of PULMICORT FLEXHALER (budesonide inhalation powder, 90 & 180 mcg), NDA 21-949, will be accompanied by the phasing out of PULMICORT TURBUHALER so as to minimize confusion in the marketplace. AstraZeneca has no further plans to manufacture NDA 20-441, PULMICORT TURBUHALER 200 mcg (budesonide inhalation powder).
Regular Iletin II (INSULIN INJECTION, USP, PURIFIED PORK) 7/6/2005	Eli Lilly and Company	Dear Doctor Letter Patient Information Frequently Asked Questions
Revex (Nalmefene HCl Injection) 1mg/mL, 2 mL ampule and 0.1mg/mL, 1mL ampule 7/9/2008	Baxter Healthcare Corporation 888-229-0001	Baxter has discontinued Revex production.
Roferon-A (Interferon alfa-2a, Recombinant) 11/29/2007	Hoffmann -La Roche Inc. 800-526-6367	Dear Healthcare Professional Letter
SecreFlo (porcine secretin for injection, 16 mcg/vial) 10/1/2008	ChiRhoClin, Inc., 1-877-272-4888	Please see Dear Healthcare Professional Letter for additional information.
Serevent Inhalation Aerosol 6/10/2003	GlaxoSmithKline 800-340-3236	GSK anticipates that SEREVENT Inhalation Aerosol will no longer be available starting in June 2003. Dear Health Care Professional Letter from GlaxoSmithKline
Sporanox (itraconazole) Injection 10/11/2007	Ortho Biotech	Please see Dear Health Care Professional letter for additional information.
Stelazine (trifluoperazine) oral concentrate 10mg/ml Stelazine (trifluoperazine) tablets (1mg, 2mg, 5mg, 10mg) Stelazine (trifluoperazine) Injection 2mg/ml 12/18/2003	GlaxoSmithKline 888-825-5249	Stelazine was discontinued and withdrawn from the market. The final lots were distributed by GSK August 2003 and the final expiry date of all products in the marketplace is no later than January 31, 2004.
Suprax (cefixime) updated 2/25/2004	Lederle/Wyeth Pharmaceuticals	Discontinued July 2002. Stock will be distributed until exhausted or until March 2003, whichever comes first. For additional information, please call customer service (800) 666-7248 Lupin Pharmaceuticals recently received approval for cefixime 400 mg tablets and cefixime 100 mg/5 ml suspension. For further information, please contact Lupin Pharmaceuticals at 410-576-2000 (2/25/2004)
Tenormin (atenolol) 0.5mg/ml Injection 2/28/2008	AstraZeneca Pharmaceuticals LP (AstraZeneca) – Contact Corporate Information Center: 800-236-9933	AstraZeneca has made a business decision to discontinue Tenormin (atenolol) 0.5 mg/ml injection.
Teslac (testolactone tablets, USP) 50mg tablets 2/26/2008	Bristol-Myers Squibb 609-897-2412	Bristol-Myers Squibb Company has made a decision to discontinue Teslac (testolactone tablets, USP) 50mg tablets. Letter from Bristol-Myers Squibb
Tequin (gatifloxacin) Tablets and Injection 5/12/2006	Bristol-Meyers Squibb	See attached letter
Tilade Inhaler (nedocromil sodium inhalation aerosol) 5/2/2008	King Pharmaceuticals 800-776-3637	Dear Healthcare Professional Letter (4/30/2008)
Valstar (valrubicin) Solution for Intravesical Instillation 1/30/2004	Formerly distributed by Celltech Celltech Customer Service 888-963-3382	No further availability planned at this time.
Velosulin BR Human, Buffered Regular Human Insulin Injection [rDNA origin] 11/3/2003	Novo Nordisk Pharmaceuticals, Inc. Contact: 800-727-6500 Customer Service	Dear Healthcare Professional Letter
Vesanoid (tretinoin) Soft Gelatin Capsule 10 mg 12/17/2009	Hoffmann-La Roche Inc	Please see the Dear Customer Letter titled: Vesanoid 10mg (tretinoin) Product Deletion at: Vesanoid Teva is increasing supply of their tretinoin 10mg capsules to meet market demand (NDC 00555-0808-02).
Videx (didanosine) chewable/dispersable buffered tablets 9/19/2006	BMS	Dear Healthcare Professional Letter
1.5% Xylocaine -MPF with Dextrose 7.5% Injection (lidocaine HCl and dextrose anhydrous Injection ampules) 8/29/2005	AstraZeneca 800-842-9920	1.5% Xylocaine® -MPF with Dextrose 7.5% Injection is no longer available at AstraZeneca. The remaining inventory of 1.5% Xylocaine® -MPF with Dextrose 7.5% Injection Ampules will be depleted by August 31, 2005. AstraZeneca has no further plans to manufacture 1.5% Xylocaine® -MPF with Dextrose 7.5% Injection Ampules
Zenapax (daclizumab) sterile Concentrate for Injection 12/18/2009	Hoffman-La Roche	Please see Dear Healthcare Professional Letter for additional information
Zovirax (acyclovir sodium) for injection 1000mg/20ml vial 1/6/2004	GlaxoSmithKline Customer Service 800-877-1158	Letter from GSK
Zyflo (zileuton) tablets 2/20/2008	Critical Therapeutics, Inc.	Zyflo CR continues to be available. Dear Healthcare Professional Letter

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