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Device for Simulating Explosive Blast Trauma

Posted Mar 01 2012 7:00pm

Description of Invention:
NIH scientists have developed a novel device to simulate the effects of pressure waves resulting from explosions or blasts on biological tissue. This methodology allows real-time monitoring of tissue damage while it is occurring and can track the secondary effects of pressure damage after tissue insult. This tool is well-adapted for investigating traumatic brain injury and organ damage resulting from explosion pressure waves, such as in military combat.

Diagram of pressure gun apparatus and specimen wells



Applications:
  • Real-time monitoring of tissue damage from primary blast pressure
  • Real-time monitoring of tissue damage from secondary effects of blast pressure, such as tissue shearing against surfaces
  • Can monitor tissue through both live imaging and assaying cell viability
  • Can measure pressure effects on various tissues


Advantages:
  • Allows differentiation of primary and secondary blast pressure effects on tissue damage
  • Employs multiple methods to assess cell viability
  • Possesses high temporal resolution


Development Status:
Prototype

Inventors:
Rea Ravin (NICHD)
Paul S Blank (NICHD)
Alex N Steinkamp (NICHD)
Joshua J Zimmerberg (NICHD)
Sergey M Bezrukov (NICHD)
Kim Lee Mcafee (NICHD)


Patent Status:
HHS, Reference No. E-068-2012/0
US, Application No. 61/590,209 filed 24 Jan 2012



For Licensing Information Please Contact:
Michael Shmilovich Esq.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: shmilovm@mail.nih.gov
Phone: 301-435-5019
Fax: 301-402-0220


Ref No: 2382

Updated: 03/2012

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